Antidepressant efficacy of sertraline and imipramine for the treatment of major depression in elderly outpatients
São Paulo med. j
; São Paulo med. j;118(4): 99-104, July 2000.
Article
en En
| LILACS
| ID: lil-264470
Biblioteca responsable:
BR1.1
RESUMO
CONTEXT Most double-blind studies of efficacy and tolerability of sertraline as compared to tricyclics in the treatment of late-life major depression have used amitriptyline as a standard, leading to the inevitable conclusion that the former drug is better tolerated than the latter, with both being equally efficacious. OBJECTIVE:
To compare the antidepressant efficacy and tolerability of sertraline (50 mg/day) and imipramine (150 mg/day) in the first 6 weeks of the treatment of major depression in the elderly.DESIGN:
A randomized double-blind parallel study with 6 weeks of follow-up.SETTING:
The psychogeriatric clinic at the Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine of the University of São Paulo.PARTICIPANTS:
55 severe and moderately depressed non-demented outpatients aged 60 years or more. INTERVENTION Patients were assigned to sertraline 50 mg/day or imipramine 150 mg/day. MAIN MEASUREMENTS CAMDEX interview. Psychiatric diagnosis followed the guidelines for "Major Depressive Episode" according to DSM-IV criteria. Severity of symptoms was evaluated using the "CGI" and "MADRS" scales. Cognitive state was assessed using the Mini-Mental State Examination. Side effects were assessed using the "Safetee-Up" schedule.RESULTS:
Both groups had a significant decrease in depressive symptoms according to the MADRS scores after 6 weeks of treatment (P = 0.01). No significant differences between groups were detected regarding treatment outcome (t = 0.4; P = 0.7). Although the dropout rate was greater in the imipramine group, the overall tolerability among patients who completed the 6-week trial was similar in both test groups.CONCLUSIONS:
Both sertraline and imipramine exhibited good efficacy and an acceptable side-effect profile for elderly depressed patients after 6 weeks of antidepressant treatment
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Sertralina
/
Depresión
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Atención Ambulatoria
/
Imipramina
/
Antidepresivos Tricíclicos
Tipo de estudio:
Clinical_trials
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
MEDICINA
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2000
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil