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Renal function in the diabetic pregnant rats
Marina-Prendes, María G; Zuccollo, Adriana; Catanzaro, Orlando L.
Afiliación
  • Marina-Prendes, María G; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica. Cátedra de Fisiologia.
  • Zuccollo, Adriana; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica. Cátedra de Fisiologia.
  • Catanzaro, Orlando L; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica. Cátedra de Fisiologia.
Acta physiol. pharmacol. ther. latinoam ; 49(2): 65-70, 1999. graf
Article en En | LILACS | ID: lil-245920
Biblioteca responsable: BR1.1
RESUMO
Diabetic nephropathy is associated with increased urinary albumin and reduce kallikrein excretion. Increased activity of the renal kallikrein-kinin system has been suggested as one of the possible mechanisms underlying diabetic hyperfiltration. The present study shown that kallikrein-kinin system is progressively increased in the diabetic-pregnant rats at 7, 14, 21 days; 48 and 7 days after pregnancy (P<0.05 vs Control). However, this increase during diabetic pregnancy did not reached the levels of control pregnancy. On the other hand albumin excretion shown a significant and progressive renal damage in the diabetic state. These findings suggest that the diabetic pregnancy could impair the renal hemodynamic, but, on the other side could modulate the vasodilatador system at pregnancy in the attempt protect the fetus.
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Colección: 01-internacional Base de datos: LILACS Asunto principal: Embarazo en Diabéticas / Calicreínas / Diabetes Mellitus Experimental / Nefropatías Diabéticas Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Acta physiol. pharmacol. ther. latinoam Asunto de la revista: FARMACOLOGIA / FISIOLOGIA / TERAPEUTICA Año: 1999 Tipo del documento: Article Pais de publicación: Argentina
Buscar en Google
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Colección: 01-internacional Base de datos: LILACS Asunto principal: Embarazo en Diabéticas / Calicreínas / Diabetes Mellitus Experimental / Nefropatías Diabéticas Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Acta physiol. pharmacol. ther. latinoam Asunto de la revista: FARMACOLOGIA / FISIOLOGIA / TERAPEUTICA Año: 1999 Tipo del documento: Article Pais de publicación: Argentina