Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
Braz. j. med. biol. res
; 32(7): 841-3, July 1999.
Article
en En
| LILACS
| ID: lil-234889
Biblioteca responsable:
BR1.1
ABSTRACT
FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Proteínas Proto-Oncogénicas c-fos
/
Receptores de Factores de Crecimiento de Fibroblastos
/
Neoplasias de la Corteza Suprarrenal
/
Hormona Adrenocorticotrópica
/
Proteína Quinasa 1 Activada por Mitógenos
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1999
Tipo del documento:
Article
/
Congress and conference
Pais de publicación:
Brasil