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Antipsychotic profile of alstonine: ethnopharmacology of a traditional Nigerian botanical remedy
Costa-Campos, L; Elisabetsky, E; Lara, D. R; Carlson, T. J; King, S. R; Ubillas, R; Nunes, D. S; Iwu, M. M; Nkemjika, Cosmas Obialor; Ozioko, Alfred; Agwu, Charles O. C.
Afiliación
  • Costa-Campos, L; Universidade Federal do Rio Grande do Sul. Departamento de Farmacologia.
  • Elisabetsky, E; Universidade Federal do Rio Grande do Sul. Departamento de Farmacologia.
  • Lara, D. R; Universidade Federal do Rio Grande do Sul. Departamento de Farmacologia.
  • Carlson, T. J; Shaman Pharmaceuticals.
  • King, S. R; Shaman Pharmaceuticals.
  • Ubillas, R; Shaman Pharmaceuticals.
  • Nunes, D. S; Universidade Federal de Ponta Grossa. Departamento de Química.
  • Iwu, M. M; University of Nigeria. Faculty of Pharmaceutical Sciences.
  • Nkemjika, Cosmas Obialor; University of Nigeria. Faculty of Pharmaceutical Sciences.
  • Ozioko, Alfred; University of Nigeria. Faculty of Pharmaceutical Sciences.
  • Agwu, Charles O. C; University of Nigeria. Faculty of Pharmaceutical Sciences.
An. acad. bras. ciênc ; 71(2): 189-201, jun. 1999. ilus, graf
Article en En | LILACS | ID: lil-234513
Biblioteca responsable: BR1.1
ABSTRACT
Although recently developed drugs have brought significant improvement, the treatment of psychotic disorders still presents serious drawbacks. Since inherent complexity and lack of satisfactory understanding of the underlying pathophysiology impose limits for rational drug design, resourceful approaches in the search for antipsychotics are pertinent. This paper reports pharmacological properties of alstonine, a heteroyohimbine type alkaloid, Which exbitited an antipsychotic-like profile, inhibiting amphetamine-induced lethaly, apomorphine-induced steotypy and potentiating barbiturate-induced slleping time. Atypical features of alstonine were the prevention of haloperidol-induced catalepsy and lack of direct interaction with D1, D2 and 5-HT2A receptors, classically linked to antipsychotic mechanism of action.
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Colección: 01-internacional Base de datos: LILACS Asunto principal: Plantas Medicinales / Antipsicóticos / Alcaloides de Triptamina Secologanina Límite: Animals País/Región como asunto: Africa Idioma: En Revista: An. acad. bras. ciênc Asunto de la revista: CIENCIA Año: 1999 Tipo del documento: Article / Congress and conference Pais de publicación: Brasil
Buscar en Google
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Colección: 01-internacional Base de datos: LILACS Asunto principal: Plantas Medicinales / Antipsicóticos / Alcaloides de Triptamina Secologanina Límite: Animals País/Región como asunto: Africa Idioma: En Revista: An. acad. bras. ciênc Asunto de la revista: CIENCIA Año: 1999 Tipo del documento: Article / Congress and conference Pais de publicación: Brasil