Inhibition of Mayaro virus replication by prostaglandin A1 and B2 in Vero cells
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;31(9): 1119-23, sept. 1998. ilus, graf
Article
en En
| LILACS
| ID: lil-222958
Biblioteca responsable:
BR1.1
ABSTRACT
The effect of prostaglandins (PGA1 and PGB2) on the replication of Mayaro virus was studied in Vero cells. PGA1 and PGB2 antiviral activity was found to be dose-dependent. However, while 10 µg/ml PGB2 inhibited virus yield by 60 percent, at the same dose PGA1 suppressed virus replication by more than 90 percent. SDS-PAGE analysis of [35S]-methionine-labelled proteins showed that PGA1 did not alter cellular protein synthesis. In infected cells, PGA1 slightly inhibited the synthesis of protein C, while drastically inhibiting the synthesis of glycoproteins E1 and E2
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Prostaglandinas A
/
Prostaglandinas B
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Replicación Viral
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Células Vero
/
Alphavirus
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1998
Tipo del documento:
Article
Pais de publicación:
Brasil