Reposta proliferativa das células T contra a cruzipaina na cardiopatia chagásica crônica / T cells proliferative responses to cruzipaina in chronic chagasic cardiopathy
Rev. Soc. Bras. Med. Trop
; 29(4): 331-9, Jul.-Aug. 1996. tab, graf, ilus
Article
en Pt
| LILACS
| ID: lil-187152
Biblioteca responsable:
BR1.1
RESUMO
In this paper, we sought to determine if chronic chagasic patients with cardiopathy could be distinguished from those displaying non-chagasic cardiopathy on the basis of T cell proliferative responses to cruzipain (GP57/51), a major antigen of T. cruzi. Assays were performed with peripheral blood mononuclear cells from 24 individuals classified as follows normal donors (n = 8), patients with non-chagasic cardiopathy (n = 8), patients with chronic chagasic cardiopathy without morbid associations (n = 8). The analysis of variance indicated that the proliferative responses stimulated by cruzipain were significantly higher in the group of chagasic patients (p = 0.0001). Turkey's multiple comparison test showed that the proliferative index medium from normal and non-chagasic cardiopathy was not significantly different from each other. We conclude that the T cell responses against T. cruzipain, as measured by proliferative indices of cells found in peripheral blood, are exclusively associated with Chagas, disease. In view of the abundance of cruzipain antigen in amastigotes it is possible that these T cell specificities contribute to the heart tissue damage observed in chronic Chagas, disease patients.
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Trypanosoma cruzi
/
Linfocitos T
/
Cardiomiopatía Chagásica
/
Proteasas de Cisteína
/
Antígenos de Protozoos
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
Pt
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
1996
Tipo del documento:
Article
Pais de publicación:
Brasil