Antinociceptive effect of purine nucleotides
Braz. j. med. biol. res
; 29(10): 1379-87, Oct. 1996. graf
Article
en En
| LILACS
| ID: lil-186189
Biblioteca responsable:
BR1.1
ABSTRACT
The antinociceptive effect of purine nucleotides administered systemically (sc) was determined using the formalin and writhing tests in adult male albino mice. The mechanisms underlying nucleotide-induced antinociception were investigated by preinjecting the animals (sc) with specific antagonists for opioid (naloxone, 1 mg/kg), purinergic P1 (caffeine, 5, 10 or 30 mg/kg); theophylline, 10 mg/kg) or purinergic P2 receptors (suramin, 100 mg/kg; Coomassie blue, 30-300 mg/kg; quinidine, 10 mg/kg). Adenosine, adenosine monophosphate (AMP), diphosphate (ADP) and triphosphate (ATP) caused a reduction in the number of writhes and in the time of licking the formalin-injected paw. Naloxone had no effect on adenosine- or adenine nucleotide-induced antinociception. Caffeine (30 mg/kg) and theophylline (10 mg/kg) reversed the antinociceptive action of adenosine and adenine nucleotide derivatives in both tests. P2 antagonists did not reverse adenine nucleotide-induced antinociception. These results suggest that the antinociceptive effect of adenine nucleotides is mediated by adenosine.
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Quinidina
/
Colorantes de Rosanilina
/
Suramina
/
Teofilina
/
Cafeína
/
Analgésicos
/
Inflamación
/
Naloxona
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1996
Tipo del documento:
Article
/
Project document
Pais de publicación:
Brasil