Tumor necrosis factor-æ in human American tegumentary leishmaniasis
Mem. Inst. Oswaldo Cruz
; 91(2): 225-9, Mar.-Apr. 1996. graf
Article
en En
| LILACS
| ID: lil-174384
Biblioteca responsable:
BR15.1
RESUMO
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine produced by activated macrophages and other cells. In order to verify whether the serum levels of TNF-alpha in American tegumentary leishmaniasis patients are associated with the process of cure or aggravation of the disease, 41 patients were studied 26 cases of cutaneous leishmaniasis (CL) and 15 of mucocutaneous leishmaniasis (MCL). During active disease the serum levels of TNF-alpha of MCL patients were significantly higher than those of CL patients and control subjects (healthy individuals and cutaneous lesions from other etiologies). The MCL patients had serum titers of TNF-alpha significantly lower at the end of antimonial therapy than before therapy. After a six-month follow-up, the MCL patients had serum levels of TNF-alpha similar to those observed at the end of the therapy as well as to those of Cl patients and control subjects. No significant variation in the serum levels of TNF-alpha was observed in CL patients throughout the study period (before, at the end of therapy and after a six-month follow-up). The possible relationship between the high TNF-alpha serum levels and severity of the disease is discussed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Factor de Necrosis Tumoral alfa
/
Leishmaniasis Cutánea
Límite:
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
1996
Tipo del documento:
Article
Pais de publicación:
Brasil