Circulating immune complexes in patients with advanced tuberculosis and their association with autoantibodies and reduced CD4 + lymphocytes
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;28(3): 331-5, Mar. 1995. tab
Article
en En
| LILACS
| ID: lil-154699
Biblioteca responsable:
BR1.1
ABSTRACT
We investigated the presence of circulating immune complexes (CICs) in serum from tuberculosis (TB) patients with different degrees of pulmonary involvement. Patients were classified into four groups according to the extent of lung involvement mild (N = 9), moderate (N = 12), moderate plus (N = 16), and severe cases (N = 10). A search for CICs by the 3.5 percent PEG precipitation test showed that the CIC values of patients with the moderate plus or severe form of pulmonary TB were significantly higher compared to healthy controls and to mild and moderate cases (P<0.01 and P<0.001, respectively). Further analysis demonstrated that increased CIC levels were associated with increased autoantibody production, since this abnormality was more prevalent in patients with advanced disease (P<0.01), who also showed a significant reduction of CD4+ T. lymphocytes. The immunoregulatory and pathogenetic implications of these findings are discussed
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Autoanticuerpos
/
Tuberculosis Pulmonar
/
Subgrupos de Linfocitos T
/
Complejo Antígeno-Anticuerpo
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Brasil