Prostaglandin A1, inhibits replication of Mayaro virus in Aedes albopictus cells
Braz. j. med. biol. res
; 28(1): 27-30, Jan. 1995. ilus
Article
en En
| LILACS
| ID: lil-153327
Biblioteca responsable:
BR1.1
ABSTRACT
Prostaglandin A1 (PGA1) reduced Mayaro virus replication in Aedes albopictus (mosquito) cells in culture. The highest nontoxic dose of PGA1, 7.5µM, decreased virus production by 90 percent. In Mayaro virus-=infected cells, PGA1 inhibited virus-specific protein synthesis. However, in mock-infected cells the presence of PGA, stimulated the synthesis of several proteins with molecular masses of 70, 57 and 23 kDa, respectively. The data obtained from this study show that PGA1 plays a role in the metabolic regulation of Aedes albopictus cells, blocking the synthesis of Mayaro virus and inducing the synthesis of cellular polypeptides
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Péptidos
/
Prostaglandinas A
/
Proteínas Virales
/
Replicación Viral
/
Alphavirus
/
Aedes
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Brasil