Role of platelets and complement in the clearance of epimastigote forms of Trypanosoma cruzy
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;27(10): 2391-9, Oct. 1994. ilus, graf
Article
en En
| LILACS
| ID: lil-152619
Biblioteca responsable:
BR1.1
ABSTRACT
1. Trypanosoma cruzi epimastigote forms are very rapidly removed from the circulation of normal and C5-deficient mice. Depletion of C3 by cobra venom factor results in a significant delay in parasite clearance. 2. During parasite clearance there is a significant decrease in the number of circulating platelets and parasite clearance is considerably delayed in thrombocytopenic animals. 3. In vitro incubation of epimastigote forms with normal mouse serum leads to the formation of parasite clumps provided that platelets are present. Innactivation of factor B or depletion of C3 prevents this phenomenon. 4. When epimastigotes are incubated with normal mouse serum they absorb one or more factors required for their aggregation with platelets. 5. It is suggested that in mice T. cruzi epimastigote forms are removed from circulation by the alternative pathway of complement activation and that both C3 and platelets are required for parasite clearance
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Trypanosoma cruzi
/
Plaquetas
/
Complemento C3
/
Complemento C5
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1994
Tipo del documento:
Article
Pais de publicación:
Brasil