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G allele of the –930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects
Ochoa, MC; Razquin, C; Zalba, G; Martínez-González, MA; Martínez, JA; Marti, A.
Afiliación
  • Ochoa, MC; University of Navarra. Department of Nutrition, Food Science, Physiology and Toxicology. Pamplona. Spain
  • Razquin, C; University of Navarra. Department of Nutrition, Food Science, Physiology and Toxicology. Pamplona. Spain
  • Zalba, G; Centre for Applied Medical Research. Division of Cardiovascular Sciences. Pamplona. Spain
  • Martínez-González, MA; University of Navarra. Department of Preventive Medicine and Public Health. Pamplona. Spain
  • Martínez, JA; University of Navarra. Department of Nutrition, Food Science, Physiology and Toxicology. Pamplona. Spain
  • Marti, A; University of Navarra. Department of Nutrition, Food Science, Physiology and Toxicology. Pamplona. Spain
J. physiol. biochem ; J. physiol. biochem;64(2): 127-134, abr.-jun. 2008. tab
Article en En | IBECS | ID: ibc-61817
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
It has been shown that NADPH oxidase plays a role in oxidative stress which hasbeen involved in the development of metabolic syndrome. The –930A/G polymorphismof the CYBA gene (that codes p22phox, a major component of the NADPHoxidase) has been associated with human hypertension and with a reduction inNADPH oxidase activity. In this work, we have examined the influence of the–930A/G polymorphism on obesity risk and insulin resistance in a case-controlstudy of Spanish subjects (n=313). In the obese group (n=159), there was a statisticallysignificant association between the GG genotype of the –930A/G polymorphismof the CYBA gene and fasting insulin levels and HOMA index. This outcomeagrees with previous findings concerning functional analyses of this polymorphismand reinforces the hypothesis that insulin resistance is associated with oxidativestress. In conclusion, a protective effect in carriers of the –930A/G polymorphism ofthe p22phox gene against insulin resistance in a population of Spanish obese adultshas been found (AU)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Polimorfismo Genético / Resistencia a la Insulina / NADPH Oxidasas / Predisposición Genética a la Enfermedad / Alelos / Obesidad Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J. physiol. biochem Año: 2008 Tipo del documento: Article
Buscar en Google
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Polimorfismo Genético / Resistencia a la Insulina / NADPH Oxidasas / Predisposición Genética a la Enfermedad / Alelos / Obesidad Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J. physiol. biochem Año: 2008 Tipo del documento: Article