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Immune infiltration could predict the efficacy of short-term radiotherapy in patients with cervical cancer
Sun, Zhiqiang; Zhang, Shuyu; Liu, Xue; Luo, Judong; Song, Jing; Liu, Hui.
Afiliación
  • Sun, Zhiqiang; Medical College of Soochow University. School of Radiation Medicine and Protection. Suzhou. China
  • Zhang, Shuyu; Medical College of Soochow University. School of Radiation Medicine and Protection. Suzhou. China
  • Liu, Xue; Nanjing Medical University. Changzhou Medical Center. The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University. Changzhou. China
  • Luo, Judong; Nanjing Medical University. Changzhou Medical Center. The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University. Changzhou. China
  • Song, Jing; Affiliated Hospital of Jiangnan University. Department of Obstetrics and Gynecology. Wuxi. China
  • Liu, Hui; Nanjing Tech University. School of Computer Science and Technology. Nanjing. China
Clin. transl. oncol. (Print) ; 25(5): 1353-1367, mayo 2023.
Article en En | IBECS | ID: ibc-219519
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Radiotherapy is the main treatment for cervical cancer. It is usually applied alone or in combination with surgery and/or chemotherapy. To explore the association between immune microenvironment of cervical cancer and radiotherapy response, we collected 20 paired cervical cancer tumor samples before and after radiotherapy and partial clinical information. With paired-end RNA-seq, we quantified the immune infiltration and tumor purity of these samples, and obtained 6350 differentially expressed genes before and after radiotherapy. With the help of R language, the function enrichment analysis and 22 immune cells infiltration analysis were carried out. Moreover, we built a random forest model based on the immune microenvironment to predict the short-term efficacy of radiotherapy. We found that the effect of radiotherapy on the immune microenvironment of stage III and IV cervical cancer patients was weaker than that of stage I and II cervical cancer patients. Radiotherapy can significantly reduce the tumor purity and increase immune infiltration. The proportions of the immune infiltrating cells are predictive of the radiotherapy efficacy. In addition, the local mucositis caused by radiotherapy can improve the curative effect of radiotherapy (AU)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Neoplasias del Cuello Uterino Límite: Female / Humans Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2023 Tipo del documento: Article
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Neoplasias del Cuello Uterino Límite: Female / Humans Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2023 Tipo del documento: Article