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Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases
Shang, Huayu; VanDusseldorp, Trisha A; Ma, Ranggui; Zhao, Yan; Cholewa, Jason; Zanchi, Nelo Eidy; Xia, Zhi.
Afiliación
  • Shang, Huayu; Chengdu Sport University. School of Sports Medicine and Health. Chengdu. China
  • VanDusseldorp, Trisha A; Kennesaw State University. Department of Exercise Science and Sport Management. Kennesaw. USA
  • Ma, Ranggui; Chengdu Sport University. School of Sports Medicine and Health. Chengdu. China
  • Zhao, Yan; Wenzhou University. College of Physical Education and Health. Exercise Physiology and Biochemistry Laboratory. Wenzhou. China
  • Cholewa, Jason; University of Lynchburg. Department of Exercise Physiology. Lynchburg. USA
  • Zanchi, Nelo Eidy; Federal University of Maranhão (UFMA). Department of Physical Education. Laboratory of Skeletal Muscle Biology and Human Strength Performance (LABFORCEH). Sao Luis. Brazil
  • Xia, Zhi; Wenzhou University. College of Physical Education and Health. Jinggangshan University. Wenzhou. China
J. physiol. biochem ; 78(4): 709-719, nov. 2022.
Article en En | IBECS | ID: ibc-216166
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
As a key mechanism to maintain cellular homeostasis under stress conditions, autophagy/mitophagy is related to the occurrence of metabolic disorders, neurodegenerative diseases, cancer, and other aging-related diseases, but the relevant signal pathways regulating autophagy have not been clarified. Mammalian sterile 20-like kinase 1 (MST1) is a central regulatory protein of many metabolic pathways involved in the pathophysiological processes of aging and aging-related diseases and has become a critical integrator affecting autophagic signaling. Recent studies show that MST1 not only suppresses autophagy through directly phosphorylating Beclin-1 and/or inhibiting the protein expression of silent information regulator 1 (SIRT1) in the cytoplasm, but also inhibits BCL2/adenovirus E1B protein-interacting protein 3 (BNIP3)–, FUN14 domain containing 1 (FUNDC1)–, and Parkin (Parkinson protein 2)–mediated mitophagy by interacting with factors such as Ras association domain family 1A (RASSF1A). Indeed, a common pharmacological strategy for anti-aging is to induce autophagy/mitophagy through MST1 inhibition. This article reviews the role and mechanism of MST1 in regulating autophagy during aging, to provide evidence for the development of drugs targeting MST1. (AU)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Autofagia / Mitocondrias Límite: Humans Idioma: En Revista: J. physiol. biochem Año: 2022 Tipo del documento: Article
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Autofagia / Mitocondrias Límite: Humans Idioma: En Revista: J. physiol. biochem Año: 2022 Tipo del documento: Article