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Role of papillary thyroid carcinoma patients with Hashimoto thyroiditis: evaluation of oxidative stress and inflammatory markers
Lopes, Natália Medeiros Dias; Lens, Hannah Mendonça; Brito, Walison Augusto da Silva; Bianchi, Julya Karen; Marinello, Poliana Camila; Cecchini, Alessandra Lourenço; Cecchini, Rubens; Armani, André.
Afiliación
  • Lopes, Natália Medeiros Dias; University Campus. Universidade Estadual de Londrina. Laboratory of Molecular Pathology. Londrina. Brazil
  • Lens, Hannah Mendonça; University Campus. Universidade Estadual de Londrina. Laboratory of Molecular Pathology. Londrina. Brazi
  • Brito, Walison Augusto da Silva; University Campus. Universidade Estadual de Londrina. Laboratory of Molecular Pathology. Londrina. Brazil
  • Bianchi, Julya Karen; University Campus. Universidade Estadual de Londrina. Laboratory of Molecular Pathology. Londrina. Brazil
  • Marinello, Poliana Camila; University Campus. Universidade Estadual de Londrina. Laboratory of Molecular Pathology. Londrina. Brazil
  • Cecchini, Alessandra Lourenço; University Campus. Universidade Estadual de Londrina. Laboratory of Molecular Pathology. Londrina. Brazil
  • Cecchini, Rubens; Universidade Estadual de Londrina. Laboratory of Physiopathology and Free Radicals. Londrina. Brazil
  • Armani, André; Universidade Estadual de Londrina. Department of Surgery. Londrina. Brazil
Clin. transl. oncol. (Print) ; 24(12): 2366-2378, dec. 2022.
Article en En | IBECS | ID: ibc-216083
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Purpose Papillary thyroid carcinoma (PTC) is the most frequent subtype of thyroid cancer; Hashimoto's thyroiditis (HT), autoimmune disease, commonly affects the thyroid gland; there is possibly a correlation between both, but the exact mechanisms that involve this relationship are still under debate. Since oxidative stress (OS) and the inflammatory environment participate in the development of several types of cancer, the objective of the present study was to establish the microenvironment and systemic participation of OS and inflammatory markers in patients with PTC and HT. Methods Blood and tissue samples were collected from 115 patients: BENIGN (n = 63); PTC (n = 27); HT (n = 15) and PTC + HT (n = 10), and sixty-three were samples from healthy individuals (control group). Results Superoxide dismutase, Catalase, reduced Glutathione, markers of lipid peroxidation and inflammation were evaluated in blood. Immunohistochemistry was performed on 3-nitrotyrosine, 4-hydroxynonenal, Ki-67 and VEGF. The results indicate that antioxidant enzymes were more active in groups with thyroid disorders compared to control, while the concentration of Reduced glutathione was reduced in BENIGN and PTC groups. When PTC and PTC + HT groups were analyzed, no significant differences were found in relation to the antioxidant defense and inflammatory markers. The ability to contain the induced lipid peroxidation was lower and a high level of malondialdehyde was observed in the PTC group. All immunohistochemical markers had higher scores in the PTC group compared to PTC + HT. Conclusion There was a more pronounced presence of OS and a greater activity of cell proliferation and angiogenesis markers in PTC than in PTC + HT group (AU)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Carcinoma Papilar / Enfermedad de Hashimoto / Cáncer Papilar Tiroideo Límite: Humans Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2022 Tipo del documento: Article
Buscar en Google
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Imprimir
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Carcinoma Papilar / Enfermedad de Hashimoto / Cáncer Papilar Tiroideo Límite: Humans Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2022 Tipo del documento: Article