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The effect of intrinsically photosensitive retinal ganglion cell (ipRGC) stimulation on axial length changes to imposed optical defocus in young adults
Chakraborty, Ranjay; Collins, Michael J; Kricancic, Henry; Davis, Brett; Alonso-Caneiro, David; Yi, Fan; Baskaran, Karthikeyan.
Afiliación
  • Chakraborty, Ranjay; Flinders University. Caring Futures Institute. Bedford Park. Australia
  • Collins, Michael J; Queensland University of Technology. School of Optometry and Vision Science. Contact Lens and Visual Optics Laboratory. Victoria Park Road. Australia
  • Kricancic, Henry; Queensland University of Technology. School of Optometry and Vision Science. Contact Lens and Visual Optics Laboratory. Victoria Park Road. Australia
  • Davis, Brett; Queensland University of Technology. School of Optometry and Vision Science. Contact Lens and Visual Optics Laboratory. Victoria Park Road. Australia
  • Alonso-Caneiro, David; Queensland University of Technology. School of Optometry and Vision Science. Contact Lens and Visual Optics Laboratory. Victoria Park Road. Australia
  • Yi, Fan; Queensland University of Technology. School of Optometry and Vision Science. Contact Lens and Visual Optics Laboratory. Victoria Park Road. Australia
  • Baskaran, Karthikeyan; Linnaeus University. Department of Medicine and Optometry. Kalmar. Sweden
J. optom. (Internet) ; 16(1)January - March 2023. ilus, tab, graf
Article en En | IBECS | ID: ibc-214430
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Purpose: The intrinsically photosensitive retinal ganglion cells (ipRGCs) regulate pupil size and circadian rhythms. Stimulation of the ipRGCs using short-wavelength blue light causes a sustained pupil constriction known as the post-illumination pupil response (PIPR). Here we examined the effects of ipRGC stimulation on axial length changes to imposed optical defocus in young adults.Materials and methodsNearly emmetropic young participants were given either myopic (+3 D, n = 16) or hyperopic (-3 D, n = 17) defocus in their right eye for 2 h. Before and after defocus, a series of axial length measurements for up to 180 s were performed in the right eye using the IOL Master following exposure to 5 s red (625 nm, 3.74 × 1014 photons/cm2/s) and blue (470 nm, 3.29 × 1014 photons/cm2/s) stimuli. The pupil measurements were collected from the left eye to track the ipRGC activity. The 6 s and 30 s PIPR, early and late area under the curve (AUC), and time to return to baseline were calculated.ResultsThe PIPR with blue light was significantly stronger after 2 h of hyperopic defocus as indicated by a lower 6 and 30 s PIPR and a larger early and late AUC (all p<0.05). Short-wavelength ipRGC stimulation also significantly exaggerated the ocular response to hyperopic defocus, causing a significantly greater increase in axial length than that resulting from the hyperopic defocus alone (p = 0.017). Neither wavelength had any effect on axial length with myopic defocus.ConclusionsThese findings suggest an interaction between myopiagenic hyperopic defocus and ipRGC signaling. (AU)
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Estimulación Luminosa / Células Ganglionares de la Retina / Pupila / Hiperopía / Luz / Miopía Límite: Humans Idioma: En Revista: J. optom. (Internet) Año: 2023 Tipo del documento: Article
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Estimulación Luminosa / Células Ganglionares de la Retina / Pupila / Hiperopía / Luz / Miopía Límite: Humans Idioma: En Revista: J. optom. (Internet) Año: 2023 Tipo del documento: Article