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Activity of energy, glutamate, and glutathione metabolism enzymes in blood cells of elderly patients with depression
Savushkina, Olga; Boksha, Irina; Prokhorova, Tatyana; Tereshkina, Elena; Safarova, Tatyana; Yakovleva, Olga; Kornilov, Vladimir; Shipilova, Elena; Vorobyeva, Elena; Burbaeva, Gulnur.
Afiliación
  • Savushkina, Olga; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Boksha, Irina; ederal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Prokhorova, Tatyana; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Tereshkina, Elena; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Safarova, Tatyana; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Yakovleva, Olga; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Kornilov, Vladimir; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Shipilova, Elena; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Vorobyeva, Elena; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
  • Burbaeva, Gulnur; Federal State Budgetary Scientific Institution “Mental Health Research Centre”. Moscow. Russia
Eur. j. psychiatry ; 36(4): 288-293, octubre 2022.
Article en En | IBECS | ID: ibc-212348
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Heterogeneity of depression in older adults is a challenge for the development of person-centered treatment. To address this, we studied glutamate and glutathione metabolism enzymes in blood cells in 53 older adult patients with depression and 20 controls. Patients with depression had decreased platelet glutathione-S-transferase and erythrocyte glutathione reductase. The biochemical and clinical data contributed to three clinical clusters that are not linked to the onset of depression or its duration but were related to anxiety, cerebrovascular and cardiovascular comorbidities, including parkinsonian features such as tremor, akathisia, and rigidity. These findings could aid person-centered diagnosis and outcomes and timely successful treatment(s) of depression in older adults. (AU)
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Pacientes / Células Sanguíneas / Depresión / 51833 / Metabolismo Límite: Aged / Humans Idioma: En Revista: Eur. j. psychiatry Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Pacientes / Células Sanguíneas / Depresión / 51833 / Metabolismo Límite: Aged / Humans Idioma: En Revista: Eur. j. psychiatry Año: 2022 Tipo del documento: Article