Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients
J. physiol. biochem
; 74(4): 569-577, nov. 2018. graf
Article
en En
| IBECS
| ID: ibc-179035
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
High-sugar intake and senescence share common deleterious effects, in particular in liver, but combination of these two factors was little studied. Our aims were to examine the effect of a high-sucrose diet in liver of old rats and also the potential benefices of a polyphenol/micronutrient supplementation. Four groups of 22-month-old male rats fed during 5 months with a diet containing either 13 or 62% sucrose, supplemented or not with rutin, vitamin E, A, D, selenium, and zinc were compared. We measured liver macronutrient composition, glycation/oxidative stress, enzyme activities (lipogenesis, Beta-oxidation, fructokinase), gene expression (enzymes and transcription factors), in vivo protein synthesis rates and plasma parameters. Sucrose induced an increase in plasma and liver lipid content, and a stimulation of liver protein synthesis rates. Gene expression was little changed by sucrose, with lower levels for LXR-alfa and LXR-Beta. Polyphenol/micronutrient supplementation tended to limit liver triglyceride infiltration through variations in fatty acid synthase, acyl coA oxidase, and possibly ATP-citrate lyase activities. In conclusion, despite differences in enzymatic regulations, and blunted responses of gene expression, high-sucrose diet was still able to induce a marked increase in liver lipid content in old animals. However, it probably attenuated the positive impact of polyphenol/micronutrients
RESUMEN
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Rutina
/
Envejecimiento
/
Suplementos Dietéticos
/
Enfermedad del Hígado Graso no Alcohólico
/
Hígado
/
Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
J. physiol. biochem
Año:
2018
Tipo del documento:
Article