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Could formaldehyde induce mutagenic and cytotoxic effects in buccal epithelial cells during anatomy classes?
Lorenzoni, Diego Coelho; Pinheiro, Leon Penido; Nascimento, Haniel Serpa; Menegardo, Cristiani Sartorio; Silva, Ronara Gerhardt; Bautz, Willian Grassi; Henriques, José Fernando; AlmeidaCoburn, Karla Loureiro; Souza, Letícia Nogueira da Gama de.
Afiliación
  • Lorenzoni, Diego Coelho; s.af
  • Pinheiro, Leon Penido; s.af
  • Nascimento, Haniel Serpa; s.af
  • Menegardo, Cristiani Sartorio; s.af
  • Silva, Ronara Gerhardt; s.af
  • Bautz, Willian Grassi; Federal University of Espírito Santo. Department of Morphology. Viória. Brazil
  • Henriques, José Fernando; University of São Paulo. Bauru Dental School. Department of Orthodontics. Bauru. Brazil
  • AlmeidaCoburn, Karla Loureiro; Federal University of Espírito Santo. Department of Morphology. Viória. Brazil
  • Souza, Letícia Nogueira da Gama de; Federal University of Espírito Santo. Department of Morphology. Viória. Brazil
Med. oral patol. oral cir. bucal (Internet) ; Med. oral patol. oral cir. bucal (Ed.impr.);22(1): e58-e63, ene. 2017. ilus, tab
Article en En | IBECS | ID: ibc-159767
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
BACKGROUND: Due to increased formaldehyde exposure, carcinogenic to humans, several researches have been studying the potential toxicity and the safe levels for human beings. The aim of this study was to investigate mutagenicity and cytotoxicity in buccal epithelial exfoliated cells (BEC) of students subjected to formaldehyde (FA) during anatomy classes. MATERIAL AND METHODS: BEC were collected periodically from 17 volunteers of undergraduate programs, who had participated in practical anatomy classes, before and after FA exposure. Cells were stained according to Feulgen method and then micronucleus test was applied. A total of 1,500 cells were assessed per individual in this study for the micronucleus frequency and other parameters of cytotoxicity. RESULTS: There was statistically significant increase in number of micronucleated BEC after FA exposure (after 1 month p=.034 and after 3.5 months p=.017). However, FA exposure caused no significant increase in other nuclear alterations closely related to cytotoxicity (p≥.05). CONCLUSIONS: FA induced mutagenicity during anatomy classes. Cell death increased, but it was not statistically significant. Efforts have to be made to improve air quality and reduce exposures during anatomy classes
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Citotoxicidad Inmunológica / Células Epiteliales / Formaldehído Límite: Humans Idioma: En Revista: Med. oral patol. oral cir. bucal (Ed.impr.) / Med. oral patol. oral cir. bucal (Internet) Año: 2017 Tipo del documento: Article
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Citotoxicidad Inmunológica / Células Epiteliales / Formaldehído Límite: Humans Idioma: En Revista: Med. oral patol. oral cir. bucal (Ed.impr.) / Med. oral patol. oral cir. bucal (Internet) Año: 2017 Tipo del documento: Article