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Exhaled nitric oxide in school children: Searching for the lost variability
Garcia Marcos, PW; Soriano Pérez, MJ; Perez Fernández, V; Valverde Molina, J.
Afiliación
  • Garcia Marcos, PW; University of Murcia. Arrixaca University Children´s Hospital. Departament of General Pediatrics. Murcia. Spain
  • Soriano Pérez, MJ; Los Arcos del Mar Menor University Hospital. Emergency Department. San Javier. Spain
  • Perez Fernández, V; University of Murcia. Arrixaca University Children´s Hospital. Departament of General Pediatrics. Murcia. Spain
  • Valverde Molina, J; Los Arcos del Mar Menor University Hospital. Department of Pediatric Respiratory Medice. San Javier. Spain
Allergol. immunopatol ; 44(3): 206-213, mayo-jun. 2016. tab, ilus, graf
Article en En | IBECS | ID: ibc-152075
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
OBJECTIVE: The factors including asthma and rhinoconjunctivitis - which influence FeNO values in a general population of school children have been studied in order to know to what extent the variability of those values can be explained. METHODS: FeNO was measured in a population of 240 school children aged 6-12 years by means of a Niox-Mino(TM) device in a standardised way. Parents filled in an ISAAC-validated questionnaire of symptoms and environmental factors. Diagnoses were checked against clinical records. Height and weight were measured. A multivariate regression analysis including all variables in the questionnaire was performed, which was followed by two Xi stepwise tests in order to build a predictive model which included the main variables influencing FeNO values. RESULTS: Among the 240 children, 10 suffered from asthma, 16 from rhinoconjunctivitis and 15 from both conditions. FeNO values (GM ± GSD) in children with rhinoconjunctivitis (19.61 ± 1.20 ppb), with asthma (18.62 ± 1.32 ppb), and with both conditions (17.62 ± 1.19 ppb) tended to be significantly higher than control children (11.42 ± 1.04 ppb), p = 0.0016, p = 0.08 and p = 0.01, respectively. The different predictive models were able to explain only 20-27% of FeNO variability. CONCLUSIONS: The proportion of FeNO inter-individual variability which can be explained by individual (including suffering from asthma or rhinoconjunctivitis), family, and environmental factors is very low (20-27%). This could have implications on the usefulness of FeNO as a diagnostic tool in asthma
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Asma / Niño / Rinitis Alérgica / Óxido Nítrico Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Allergol. immunopatol Año: 2016 Tipo del documento: Article
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Asma / Niño / Rinitis Alérgica / Óxido Nítrico Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Allergol. immunopatol Año: 2016 Tipo del documento: Article