Hereditary pancreatic cancer: molecular bases and their application in diagnosis and clinical management: a guideline of the TTD group
Clin. transl. oncol. (Print)
; Clin. transl. oncol. (Print);14(8): 553-563, ago. 2012.
Article
en En
| IBECS
| ID: ibc-126951
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Pancreatic carcinoma (PC) represents the fourth leading cause of cancer death in Spain with a death rate of 2,400 males and 2,000 females per year. Poor outcome related to its silent nature and the lack of reliable secondary prevention measures translate into advanced-stage diagnosis, 75 % of deaths within the first year of diagnosis and 5-year survival rate of <5 %. Family history was first recognized as a risk factor for PC. Further population-based and case-control studies subsequently found that 7.8 % of patients with PC have a family history of the same tumor and individuals with a first-degree relative with PC have a 3.2-fold increased risk of developing PC. Overall, it is estimated that up to 10 % of PC have a familial component. However, known genetic syndromes account for <20 % of the observed familial aggregation of PC. We review the most important aspects in epidemiology, molecular biology and clinical management of familial PC (AU)
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Neoplasias Pancreáticas
/
Lesiones Precancerosas
/
Carcinoma
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Año:
2012
Tipo del documento:
Article