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Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)
Bachmeier, Evelin; Mazzeo, Marcelo-Adrián; López, María-Marcela; Linares, Jorge-Alberto; Jarchum, Gustavo; Wietz, Fernando-Martín; Finkelberg, Ana-Beatriz.
Afiliación
  • Bachmeier, Evelin; Córdoba National University. Faculty of Odontology. Chair of Clinical Stomatology "A" and Chair of Physiology. s.c. s.p
  • Mazzeo, Marcelo-Adrián; Córdoba National University. Chair of Physiology. s.c. s.p
  • López, María-Marcela; Córdoba National University. Faculty of Odontology. s.c. s.p
  • Linares, Jorge-Alberto; Córdoba National University. Chair of Physiology. s.c. s.p
  • Jarchum, Gustavo; Córdoba National University. Faculty of Odontology. s.c. s.p
  • Wietz, Fernando-Martín; Córdoba National University. Faculty of Odontology. s.c. s.p
  • Finkelberg, Ana-Beatriz; Córdoba National University. Faculty of Odontology. s.c. s.p
Med. oral patol. oral cir. bucal (Internet) ; Med. oral patol. oral cir. bucal (Ed.impr.);19(5): e444-e450, sept. 2014. ilus, tab
Article en En | IBECS | ID: ibc-126462
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
OBJECTIVES: High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva. STUDY DESIGN: Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used.RESULTS:85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values. CONCLUSIONS: SOD increase in stage M coincided with the appearance of mucositis, which could be interpreted as a defensive mechanism of saliva against oxidative stress produced by chemotherapy. UA decrease in stage M would favour the development of higher degrees of mucositis
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Estomatitis / Superóxido Dismutasa / Trasplante de Médula Ósea / Especies Reactivas de Oxígeno / Antioxidantes Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Med. oral patol. oral cir. bucal (Ed.impr.) / Med. oral patol. oral cir. bucal (Internet) Año: 2014 Tipo del documento: Article
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Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Estomatitis / Superóxido Dismutasa / Trasplante de Médula Ósea / Especies Reactivas de Oxígeno / Antioxidantes Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Med. oral patol. oral cir. bucal (Ed.impr.) / Med. oral patol. oral cir. bucal (Internet) Año: 2014 Tipo del documento: Article