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Tumour cells resistance in cancer therapy
Martínez-Lacaci, I; García Morales, P; Soto, J. L; Saceda, M.
Afiliación
  • Martínez-Lacaci, I; Miguel Hernández University. Instituto de Biología Molecular y Celular. Elche. Spain
  • García Morales, P; Hospital General Universitario de Elche. Elche. Spain
  • Soto, J. L; Hospital General Universitario de Elche. Elche. Spain
  • Saceda, M; Hospital General Universitario de Elche. Elche. Spain
Clin. transl. oncol. (Print) ; 9(1): 13-20, ene. 2007. ilus
Article en En | IBECS | ID: ibc-123260
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature(AU)
Asunto(s)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Adenocarcinoma / Muerte Celular / Carcinoma de Células Gigantes / Resistencia a Múltiples Medicamentos / Genes MDR / Quimioterapia / Fluorouracilo Límite: Animals Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2007 Tipo del documento: Article
Buscar en Google
Colección: 06-national / ES Base de datos: IBECS Asunto principal: Adenocarcinoma / Muerte Celular / Carcinoma de Células Gigantes / Resistencia a Múltiples Medicamentos / Genes MDR / Quimioterapia / Fluorouracilo Límite: Animals Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2007 Tipo del documento: Article