Reproductive axis response to repeated lipopolysaccharide administration in peripubertal female rats
J. physiol. biochem
; J. physiol. biochem;66(3): 237-244, sept. 2010.
Article
en En
| IBECS
| ID: ibc-122829
Biblioteca responsable:
ES1.1
Ubicación: BNCS
RESUMEN
No disponible
ABSTRACT
Immune system disorders are often accompanied by alterations in the reproductive axis. Several reports have shown that administration of bacterial lipopolysaccharide (LPS) has central inflammatory effects and activates cytokine release in the hypothalamus where the luteinizing hormone releasing hormone (Gn-RH) neurons are located. The present study was designed to investigate the effect of repeated LPS administration on the neuroendocrine mechanisms of control of the reproductive axis in peripubertal female rats (30-day-old rats). With this aim, LPS (50 ìg/kg weight) was administered to the animals during 25, 27 and 29 days of age and sacrificed on 30 day of life. Gn-RH, ã−amino butyric acid (GABA) and glutamic acid (GLU), two amino acids involved in the regulation of Gn-RH secretion, hypothalamic content were measured. LH and estradiol serum levels were also determined and the day of vaginal opening examined. The results showed a significant increase in Gn-RH and GLU content (p < 0.0001), shared by a reduction of GABA one (p < 0.0001). LH and estradiol serum levels were decreased (p < 0.01, p < 0.001) and delay in the day of vaginal opening was also observed in treated animals. Present results show that repeated LPSadministration impaired reproductive function, modifying the neuroendocrine mechanisms of control of the axis in peripubertal female rats (AU)
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Lipopolisacáridos
/
Fenómenos Fisiológicos Reproductivos
Límite:
Animals
Idioma:
En
Revista:
J. physiol. biochem
Año:
2010
Tipo del documento:
Article