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Clinical value of morphine, pholcodine and poppy seed IgE assays in drug-abusers and allergic people
Armentia, A; Ruiz-Muñoz, P; Quesada, JM; Postigo, I; Herrero, M; Martín-Gil, FJ; Gonzalez-Sagrado, M; Martín, B; Castrodeza, J.
Afiliación
  • Armentia, A; Rio Hortega University Hospital. Allergy Unit. Valladolid. Spain
  • Ruiz-Muñoz, P; San Juan de Dios Centre. Palencia and Castile-Leon Association For the Aid of Drug Abusers. Valladolid. Spain
  • Quesada, JM; University of the Basque Country. Immunology, Microbiology and Parasitology Department. Vitoria. Spain
  • Postigo, I; University of the Basque Country. Immunology, Microbiology and Parasitology Department. Vitoria. Spain
  • Herrero, M; Rio Hortega University Hospital. Allergy Unit. Valladolid. Spain
  • Martín-Gil, FJ; Rio Hortega University Hospital. Clinical Chemistry Service. Valladolid. Spain
  • Gonzalez-Sagrado, M; Rio Hortega University Hospital. Research Unit. Valladolid. Spain
  • Martín, B; Rio Hortega University Hospital. Research Unit. Valladolid. Spain
  • Castrodeza, J; Direction of Public Health, Investigation, Development and Innovation. Valladolid. Spain
Allergol. immunopatol ; 41(1): 37-44, ene.-feb. 2013. ilus, tab
Article en En | IBECS | ID: ibc-109466
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
Background: The diagnosis of anaphylactic reactions due to opiates during anaesthesia can be difficult, since in most cases various drugs may have been administered. Detection of specific IgE to poppy seed might be a marker for sensitisation to opiates in allergic people and heroin-abusers. This study assessed the clinical value of morphine, pholcodine and poppy seed skin-prick and IgE determination in people suffering hypersensitivity reactions during anaesthesia or analgesia and drug-abusers with allergic symptoms. Methods: We selected heroin abusers and patients who suffered severe reactions during anaesthesia and analgesia from a database of 23,873 patients. The diagnostic yield (sensitivity, specificity and predictive value) of prick and IgE tests in determining opiate allergy was analysed. Results: Overall, 149 patients and 200 controls, mean age 32.9±14.7 years, were included. All patients with positive prick to opiates showed positive prick and IgE to poppy seeds, but not to morphine or pholcodine IgE. Among drug-abusers, 13/42 patients (31%) presented opium hypersensitivity confirmed by challenge tests. Among non-drug abusers, sensitisation to opiates was higher in people allergic to tobacco (25%), P<0.001. Prick tests and IgE against poppy seed had a good sensitivity (95.6% and 82.6%, respectively) and specificity (98.5% and 100%, respectively) in the diagnosis of opiate allergy. Conclusions: Opiates may be significant allergens. Drug-abusers and people sensitised to tobacco are at risk. Both the prick and specific IgE tests efficiently detected sensitisation to opiates. The highest levels were related to more-severe clinical profiles(AU)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Inmunoglobulina E / Receptores de IgE / Trastornos Relacionados con Sustancias / Hipersensibilidad / Morfina Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Allergol. immunopatol Año: 2013 Tipo del documento: Article
Buscar en Google
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Inmunoglobulina E / Receptores de IgE / Trastornos Relacionados con Sustancias / Hipersensibilidad / Morfina Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Allergol. immunopatol Año: 2013 Tipo del documento: Article