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Premenstrual asthma and leukotriene variations in the menstrual cycle
Pereira-Vega, A; Sánchez Ramos, JL; Maldonado Pérez, JA; Vázquez Oliva, R; Bravo Nieto, JM; Vázquez Rico, I; Ignacio García, JM; Romero Palacios, P; Alwakil Olbah, M; Medina Gallardo, JF.
Afiliación
  • Pereira-Vega, A; Hospital Juan Ramón Jiménez. Pneumology Section. Huelva. Spain
  • Sánchez Ramos, JL; Universidad de Huelva, Campus del Carmen. Department of Nursing. Huelva. Spain
  • Maldonado Pérez, JA; Hospital Juan Ramón Jiménez. Pneumology Section. Huelva. Spain
  • Vázquez Oliva, R; Hospital Infanta Elena. Pneumology Section. Huelva. Spain
  • Bravo Nieto, JM; Hospital Juan Ramón Jiménez. Pneumology Section. Huelva. Spain
  • Vázquez Rico, I; Hospital Juan Ramón Jiménez. Laboratory Service. Huelva. Spain
  • Ignacio García, JM; Hospital de la Serranía de Ronda. Pneumology Section. Málaga. Spain
  • Romero Palacios, P; Hospital de Baza. Pneumology Section. Granada. Spain
  • Alwakil Olbah, M; Hospital Juan Ramón Jiménez. Pneumology Section. Huelva. Spain
  • Medina Gallardo, JF; Hospital Virgen del Rocío. Pneumology Service. Sevilla. Spain
Allergol. immunopatol ; 40(6): 368-373, nov.-dic. 2012. tab, graf
Article en En | IBECS | ID: ibc-107718
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
Background: Several authors have reported an increase in leukotriene C4 in the premenstrual phase in women with severe premenstrual asthma, indicating that antileukotrienes could be used in treatment. Objective: To analyse the role of leukotrienes in premenstrual asthma. Methods: A questionnaire on respiratory symptoms and peak flow during one complete menstrual cycle was given to women of fertile age to define them as asthmatics who suffered from premenstrual asthma or not. Premenstrual asthma (PMA) was defined as a clinical or functional deterioration (major=20%) in the premenstrual phase compared with the preovulatory phase. Blood samples to measure leukotriene C4 were taken during the preovulatory and premenstrual phases. Results: Blood samples were taken in 62 asthmatic women, 34 of whom (54.3%) presented PMA criteria, all with a premenstrual deterioration of between 20 and 40%. There was no difference in leukotriene C4 levels between the preovulatory and premenstrual phases in the women who suffered from PMA (1.50ng/mL vs. 1.31ng/mL; p=0.32) and those who did not (1.40ng/mL vs. 1.29ng/mL; p=0.62). Neither were there any differences in leukotriene levels between women with or without PMA. The results were similar for each category of asthma severity. Conclusions: Our data show that leukotriene C4 does not appear to be involved in the pathogenesis of premenstrual asthma, or support the use of anti-leukotrienes in the specific treatment of premenstrual asthma, at least in women with a moderate premenstrual deterioration. No differences appeared in any of the categories of asthma severity(AU)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Asma / Síndrome Premenstrual / Leucotrienos Límite: Adult / Female / Humans Idioma: En Revista: Allergol. immunopatol Año: 2012 Tipo del documento: Article
Buscar en Google
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Asma / Síndrome Premenstrual / Leucotrienos Límite: Adult / Female / Humans Idioma: En Revista: Allergol. immunopatol Año: 2012 Tipo del documento: Article