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A synthetic conjugate polysaccharide vaccine against Haemophilus influenzae type b
Verez Bencomo, V; Fernández Santana, V; Hardy, E; Toledo, ME; Rodríguez, MC; Heynngnezz, L; Rodriguez, A; Baly, A; Herrera, L; Izquierdo, M; Villar, H; Valdés, Y; Cosme, K; Deler, ML; Diaz, M; Roy, R.
Afiliación
  • Verez Bencomo, V; Universidad de La Habana. Center for the Study of Synthetic Antigens. La Habana. Cuba
  • Fernández Santana, V; Universidad de La Habana. Center for the Study of Synthetic Antigens. La Habana. Cuba
  • Hardy, E; Center for Genetic Engineering and Biotechnology. La Habana. Cuba
  • Toledo, ME; Institute for Tropical Medicine Pedro Kouri. La Habana. Cuba
  • Rodríguez, MC; s.af
  • Heynngnezz, L; Center for Genetic Engineering and Biotechnology. La Habana. Cuba
  • Rodriguez, A; Center for Genetic Engineering and Biotechnology. La Habana. Cuba
  • Baly, A; s.af
  • Herrera, L; Center for Genetic Engineering and Biotechnology. La Habana. Cuba
  • Izquierdo, M; Center for Genetic Engineering and Biotechnology. La Habana. Cuba
  • Villar, H; s.af
  • Valdés, Y; s.af
  • Cosme, K; s.af
  • Deler, ML; s.af
  • Diaz, M; s.af
  • Roy, R; Université du Québec à Montréal. Department of Chemistry. Montreal. Canada
Science ; 305(5683)July 2004.
Article en En | CUMED | ID: cum-40097
Biblioteca responsable: CU1.1
ABSTRACT
Glycoconjugate vaccines provide effective prophylaxis against bacterial infections. To date, however, no commercial vaccine has been available in which the key carbohydrate antigens are produced synthetically. We describe the large-scale synthesis, pharmaceutical development, and clinical evaluation of a conjugate vaccine composed of a synthetic capsular polysaccharide antigen of Haemophilus influenzae type b (Hib). The vaccine was evaluated in clinical trials in Cuba and showed long-term protective antibody titers that compared favorably to licensed products prepared with the Hib polysaccharide extracted from bacteria. This demonstrates that access to synthetic complex carbohydrate-based vaccines is feasible and provides a basis for further development of similar approaches for other human pathogens(AU)
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Texto completo: 1 Colección: 06-national / CU Base de datos: CUMED Asunto principal: Vacunas contra Haemophilus / Haemophilus influenzae tipo b Límite: Adult / Child / Humans Idioma: En Revista: Science Año: 2004 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 06-national / CU Base de datos: CUMED Asunto principal: Vacunas contra Haemophilus / Haemophilus influenzae tipo b Límite: Adult / Child / Humans Idioma: En Revista: Science Año: 2004 Tipo del documento: Article