Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats
Braz J Med Biol Res, v. 55, p. 1-14, set. 2022
Article
en En
| SES-SP, SESSP-IBPROD, SES-SP
| ID: bud-4390
Biblioteca responsable:
BR78.1
ABSTRACT
There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats
Texto completo:
1
Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-IBPROD
Tipo de estudio:
Clinical_trials
/
Guideline
Aspecto:
Patient_preference
Idioma:
En
Revista:
Braz J Med Biol Res
Año:
2022
Tipo del documento:
Article