Effect of beta adrenergic blockade on surviving to acute hypoxia in mice.
Acta Physiol Lat Am
; 25(2): 128-33, 1975.
Article
en En
| BINACIS
| ID: bin-48401
Biblioteca responsable:
AR1.1
ABSTRACT
A significant protection against the lethal effects of hypobaric and isobaric hypoxia is observed in mice treated with propranolol. Previous acclimatization to chronic hypoxia does not introduce variations on this protective effect of the beta adrenergic blocking drugs. Similar effects were found using histotoxic anoxia provoked by sodium azide administration. A significative reduction of body temperature is observed under the effects of the blockaders. These findings suggest a reduced need of oxygen in the treated animals. Neutralization of the effects of epinephrine released as a consequence of the hypoxic stress is proposed as the protection mechanism.
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Colección:
06-national
/
AR
Base de datos:
BINACIS
Idioma:
En
/
Es
Revista:
Acta Physiol Lat Am
/
Acta physiol. latinoam
Año:
1975
Tipo del documento:
Article
Pais de publicación:
Argentina