Evolución del clon de la hemoglobinuria paroxística nocturna en la crisis hemolítica de una anemia aplásica. Estudio por citometría de flujo. / [Evolution of paroxysmal nocturnal hemoglobinuria clone during an hemolytic crisis in a patient with aplastic anemia. Flow cytometry study]
Medicina [B Aires]
; 61(5 Pt 1): 581-4, 2001.
Article
en Es
| BINACIS
| ID: bin-39409
Biblioteca responsable:
AR2.1
ABSTRACT
The expansion of paroxysmal nocturnal hemoglobinuria (PHN) clone was evaluated in a patient with aplastic anemia (AA) of 18 years of evolution during an hemolytic crisis. On day 0, Ham and Sucrosa tests were positive and hematological parameters were altered. Low hemoglobin (Hb) levels and erythrocyte and leukocyte counts were found and continued decreasing on days 7 and 24 (last day of study). High LDH levels, indirect bilirubin and reticulocyte counts were detected throughout. We evaluated CD55 and CD59 on erythrocytes by flow cytometry. Our results showed low CD55 expression with respect to the normal pattern. Since day 0, CD59 staining detected two red cell populations PNH I (48
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Colección:
06-national
/
AR
Base de datos:
BINACIS
Idioma:
Es
Revista:
Medicina [B Aires]
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Argentina