Striatal cytomegalic neurons containing nitric oxide are associated with experimental perinatal asphyxia: implication of cold treatment
Medicina [B.Aires]
; 56(2): 169-72, 1996. tab, graf
Article
en En
| BINACIS
| ID: bin-22371
Biblioteca responsable:
BR1.1
ABSTRACT
Neuropathological mechanisms triggered by excitatory aminoacids are Known to involve nitric oxide (NO). Neurons containing NO are histochemically reactive to nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), which labels NO synthase in CNS, Sprague-Dawley male rats subjected to perinatal asphyxia (PA) at 37 degreese Celsius, and PA plus 15 degreese Celsius hypothermia were evaluted when 6 months old by NADPH-d histochemical reaction. Computarized image analysis was used for quantification of stained sections. NADPH-d neurons in striatum from subsevere and severe PA showed a significant increment in soma size and dendritic process length versus control and hypothermic treated rats. Post-ischemic damage reurons are therefore involved in NO changes induced by PA that may be prevented by hypothermia treatment. (AU)
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Colección:
06-national
/
AR
Base de datos:
BINACIS
Asunto principal:
Asfixia Neonatal
/
Cuerpo Estriado
/
NADPH Deshidrogenasa
/
Neuronas
/
Óxido Nítrico
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Medicina [B.Aires]
Año:
1996
Tipo del documento:
Article