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Association of angiotensin-converting enzyme insertion/deletion polymorphism with recurrent pregnancy loss: a meta-analysis of 26 case-control studies
Aslbahar, Fereshteh; Neamatzadeh, Hossein; Tabatabaiee, Razieh Sadat; Karimi-Zarchi, Mojgan; Javaheri, Atiyeh; Mazaheri, Mahta; Foroughi, Elnaz; Nasiri, Rezvan.
Afiliación
  • Aslbahar, Fereshteh; Semnan University of Medical Sciences. Department of Obstetrics and Gynecology. Semnan. IR
  • Neamatzadeh, Hossein; Semnan University of Medical Sciences. Department of Obstetrics and Gynecology. Semnan. IR
  • Tabatabaiee, Razieh Sadat; Shahid Sadoughi University of Medical Sciences. Department of Obstetrics and Gynecology. Yazd. IR
  • Karimi-Zarchi, Mojgan; Shahid Sadoughi University of Medical Sciences. Department of Obstetrics and Gynecology. Yazd. IR
  • Javaheri, Atiyeh; Shahid Sadoughi University of Medical Sciences. Department of Obstetrics and Gynecology. Yazd. IR
  • Mazaheri, Mahta; Shahid Sadoughi University of Medical Sciences. Mother and Newborn Health Research Center. Yazd. IR
  • Foroughi, Elnaz; Arak University of Medical Sciences. Department of Pediatric Dentistry. Arak. IR
  • Nasiri, Rezvan; Arak University of Medical Sciences. Department of Pediatric Dentistry. Arak. IR
Rev. bras. ginecol. obstet ; 40(10): 631-641, Oct. 2018. tab, graf
Article en En | LILACS | ID: biblio-977788
Biblioteca responsable: BR1.1
ABSTRACT
Abstract Objective Previous studies investigating the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and recurrent pregnancy loss (RPL) risk has provided inconsistent results. The aim of our study was to assess the association between the ACE I/D polymorphism and risk of RPL. Methods All studies published up to January 30, 2018 on the association of ACE I/D polymorphism with RPL were identified by searching the PubMed, Web of Knowledge, and Google scholar databases. Results A total of 26 case-control studies with 3,140 RPL cases and 3,370 controls were included in themeta-analysis. Overall, there was a significant association between ACE I/D polymorphism and RPL risk under the allele model (I versus D odds ratio [OR] = 0.538, 95% confidence interval [CI] = 0.451-0.643, p 0.001), the homozygote model (II versus DD OR = 0.766, 95% CI = 0.598-0.981, p = 0.035) and the recessive model (II versus ID + DD OR = 0.809, 95% CI = 0.658-0.994, p = 0.044). Subgroup analysis by ethnicity showed that there was a significant association between ACE I/D polymorphism and increased risk of RPL in Caucasian and West-Asian populations, but not in East-Asians. When stratified by number of recurrent miscarriages (RMs), a significant association between ACE I/D polymorphism and increased risk of RPL was detected in the group of studies with ≥ 2 RMs, but not in studies with ≥ 3 RMs. Conclusion Themeta-analysis suggests that ACE I/D polymorphism is associated with increased risk of RPL. The ACE I/D polymorphism may be a risk factor for RPL in Caucasian and West-Asian populations, but not in East-Asians.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Aborto Habitual / Peptidil-Dipeptidasa A / Polimorfismo de Nucleótido Simple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Pregnancy Idioma: En Revista: Rev. bras. ginecol. obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Aborto Habitual / Peptidil-Dipeptidasa A / Polimorfismo de Nucleótido Simple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Pregnancy Idioma: En Revista: Rev. bras. ginecol. obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Brasil