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Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology
Bordon, Karla C. F; Wiezel, Gisele A; Amorim, Fernanda G; Arantes, Eliane C.
Afiliación
  • Bordon, Karla C. F; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
  • Wiezel, Gisele A; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
  • Amorim, Fernanda G; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
  • Arantes, Eliane C; University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Physics and Chemistry. Ribeirão Preto. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;21: 43, 31/03/2015. tab, graf
Article en En | LILACS, VETINDEX | ID: biblio-954759
Biblioteca responsable: BR68.1
ABSTRACT
Hyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan of the interstitial matrix. They are involved in several pathological and physiological activities including fertilization, wound healing, embryogenesis, angiogenesis, diffusion of toxins and drugs, metastasis, pneumonia, sepsis, bacteremia, meningitis, inflammation and allergy, among others. Hyaluronidases are widely distributed in nature and the enzymes from mammalian spermatozoa, lysosomes and animal venoms belong to the subclass EC 3.2.1.35. To date, only five three-dimensional structures for arthropod venom hyaluronidases (Apis mellifera and Vespula vulgaris) were determined. Additionally, there are four molecular models for hyaluronidases fromMesobuthus martensii, Polybia paulista and Tityus serrulatus venoms. These enzymes are employed as adjuvants to increase the absorption and dispersion of other drugs and have been used in various off-label clinical conditions to reduce tissue edema. Moreover, a PEGylated form of a recombinant human hyaluronidase is currently under clinical trials for the treatment of metastatic pancreatic cancer. This review focuses on the arthropod venom hyaluronidases and provides an overview of their biochemical properties, role in the envenoming, structure/activity relationship, and potential medical and biotechnological applications.(AU)
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Venenos de Artrópodos / Cicatrización de Heridas / Biotecnología / Preparaciones Farmacéuticas / Ácido Hialurónico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Venenos de Artrópodos / Cicatrización de Heridas / Biotecnología / Preparaciones Farmacéuticas / Ácido Hialurónico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil