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Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats
Rosca, A E; Stoian, I; Badiu, C; Gaman, L; Popescu, B O; Iosif, L; Mirica, R; Tivig, I C; Stancu, C S; Caruntu, C; Voiculescu, S E; Zagrean, L.
Afiliación
  • Rosca, A E; Carol Davila University of Medicine and Pharmacy. Department of Physiology. Bucharest. RO
  • Stoian, I; Carol Davila University of Medicine and Pharmacy. Department of Biochemistry. Bucharest. RO
  • Badiu, C; Carol Davila University of Medicine and Pharmacy. Department of Endocrinology. C.I. Parhon National Institute of Endocrinology. Bucharest. RO
  • Gaman, L; Carol Davila University of Medicine and Pharmacy. Department of Biochemistry. Bucharest. RO
  • Popescu, B O; Carol Davila University of Medicine and Pharmacy. Department of Neurology. Colentina Clinical Hospital. Bucharest. RO
  • Iosif, L; Carol Davila University of Medicine and Pharmacy. Department of Biochemistry. Bucharest. RO
  • Mirica, R; Carol Davila University of Medicine and Pharmacy. Department of Physiology. Bucharest. RO
  • Tivig, I C; R&D Irist Labmed. Bucharest. RO
  • Stancu, C S; N. Simionescu Institute of Cellular Biology and Pathology. Department of Lipoproteins and Atherosclerosis. Bucharest. RO
  • Caruntu, C; Carol Davila University of Medicine and Pharmacy. Department of Physiology. Bucharest. RO
  • Voiculescu, S E; Carol Davila University of Medicine and Pharmacy. Department of Physiology. Bucharest. RO
  • Zagrean, L; Carol Davila University of Medicine and Pharmacy. Department of Physiology. Bucharest. RO
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;49(6): e5116, 2016. tab, graf
Article en En | LILACS | ID: biblio-951683
Biblioteca responsable: BR1.1
ABSTRACT
Supraphysiological administration of anabolic androgenic steroids has been linked to increased blood pressure. The widely distributed amino acid taurine seems to be an effective depressor agent in drug-induced hypertension. The purpose of this study was to assess the impact of chronic high dose administration of nandrolone decanoate (DECA) and taurine on blood pressure in rats and to verify the potentially involved mechanisms. The study was conducted in 4 groups of 8 adult male Wistar rats, aged 14 weeks, treated for 12 weeks with DECA (A group); vehicle (C group); taurine (T group), or with both drugs (AT group). Systolic blood pressure (SBP) was measured at the beginning of the study (SBP1), 2 (SBP2) and 3 months (SBP3) later. Plasma angiotensin-converting enzyme (ACE) activity and plasma end products of nitric oxide metabolism (NOx) were also determined. SBP3 and SBP2 were significantly increased compared to SBP1 only in the A group (P<0.002 for both). SBP2, SBP3 and ACE activity showed a statistically significant increase in the A vs C (P<0.005), andvs AT groups (P<0.05), while NOx was significantly decreased in the A and AT groups vs controls (P=0.01). ACE activity was strongly correlated with SBP3 in the A group (r=0.71, P=0.04). These findings suggest that oral supplementation of taurine may prevent the increase in SBP induced by DECA, an effect potentially mediated by angiotensin-converting enzyme.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Presión Sanguínea / Anabolizantes / Nandrolona Tipo de estudio: Evaluation_studies Límite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Presión Sanguínea / Anabolizantes / Nandrolona Tipo de estudio: Evaluation_studies Límite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Brasil