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Green Tropical Phytoextracts - Promising Anticancer Alternative
Khan, Abid Ali; Omer, Kosar Ali; Talib, Ayesha; Ahmed, Haroon; Javed, Mohamad Arshad; Sarmidi, Roji Mohamad.
Afiliación
  • Khan, Abid Ali; COMSATS Institute of Information Technology. Department of Biosciences. Islamabad. PK
  • Omer, Kosar Ali; Universiti Teknologi Malaysia. Institute of Bioproduct Development. Skudai. MY
  • Talib, Ayesha; COMSATS Institute of Information Technology. Department of Biosciences. Islamabad. PK
  • Ahmed, Haroon; COMSATS Institute of Information Technology. Department of Biosciences. Islamabad. PK
  • Javed, Mohamad Arshad; Universiti Teknologi Malaysia. Faculty of Biosciences & Bioengineering. Department of Industrial Biotechnology. Johor Bahru. MY
  • Sarmidi, Roji Mohamad; Universiti Teknologi Malaysia. Institute of Bioproduct Development. Skudai. MY
Braz. arch. biol. technol ; Braz. arch. biol. technol;59: e16160062, 2016. tab, graf
Article en En | LILACS | ID: biblio-951395
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT The anticancer potential of aqueous extracts of tropical plants Ficus deltoidea and Labisia pumila were tested on human prostate carcinoma (DU145) cells. The effects of these extracts on the cells were observed through several tests such as cytotoxicity MTT assay, trypan blue exclusion assay (for cell viability), fluorescence and morphological observations. Both of the plant extracts had a growth repression effect on the cells with different concentrations. The best concentration (1x10-3 μg/mL) was chosen by determining their cytotoxic effects on human prostate cancer as well as fibroblast (normal) cells. The F. deltoidea extract showed more potency and killed the cells faster than L. pumila. Morphologically both extracts affected the cells in a similar way, i.e. the cells became irregular shaped, detached themselves and kept floating in the medium.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Braz. arch. biol. technol Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Malasia / Pakistán Pais de publicación: Brasil
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Braz. arch. biol. technol Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Malasia / Pakistán Pais de publicación: Brasil