Effects of sodium nitroprusside in the prevention of schizophrenia-like symptoms induced by ketamine - A translational double-blind study
Rev. psiquiatr. clín. (São Paulo)
; 44(6): 149-153, Nov.-Dec. 2017. graf
Article
en En
| LILACS
| ID: biblio-903047
Biblioteca responsable:
BR66.1
ABSTRACT
Abstract Background:
Recent evidence has shown improvements in schizophrenia symptoms after the infusion of sodium nitroprusside (SNP), a nitric oxide (NO) donor. In the rat model of schizophrenia using ketamine injection, pretreatment with SNP seems to prevent behavioral changes associated with positive symptoms for up to one week.Objective:
We investigated whether SNP would have preventative effects on psychogenic symptoms induced by ketamine in healthy subjects.Methods:
Healthy subjects (N = 38) were assigned to distinct groups that received SNP in different doses (0.15, 0.25, and 0.5 mcg/kg/min). First, participants received an infusion of SNP or placebo over 75 minutes. After 10 minutes, they were injected for 1 minute with a bolus of 0.26 mg/kg of ketamine and a maintenance dose was started 5 minutes later, with 0.25 mg/kg/h of ketamine for 50 minutes.Results:
Ketamine-induced psychopathological alterations induced were reduced by SNP, as assessed with the Brief Psychological Rating Scale. Scores in the objective subscale of the Clinician-Administered Dissociative States Scale were also lower in SNP sessions compared to placebo. SNP had protective effects against deterioration in facial emotion and identity recognition tasks induced by ketamine.Discussion:
Our findings support the view that SNP has preventative properties against psychotic manifestations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Rev. psiquiatr. clín. (São Paulo)
Año:
2017
Tipo del documento:
Article
País de afiliación:
Brasil