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Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases
Chachá, Silvana Gama Florencio; Gomes-Gouvêa, Michele Soares; Malta, Fernanda de Mello; Ferreira, Sandro da Costa; Villanova, Márcia Guimarães; Souza, Fernanda Fernandes; Teixeira, Andreza Correa; Passos, Afonso Dinis da Costa; Pinho, João Renato Rebello; Martinelli, Ana de Lourdes Candolo.
Afiliación
  • Chachá, Silvana Gama Florencio; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Gomes-Gouvêa, Michele Soares; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Malta, Fernanda de Mello; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Ferreira, Sandro da Costa; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Villanova, Márcia Guimarães; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Souza, Fernanda Fernandes; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Teixeira, Andreza Correa; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Passos, Afonso Dinis da Costa; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Pinho, João Renato Rebello; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
  • Martinelli, Ana de Lourdes Candolo; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
Mem. Inst. Oswaldo Cruz ; 112(9): 626-631, Sept. 2017. tab
Article en En | LILACS | ID: biblio-894874
Biblioteca responsable: BR1.1
ABSTRACT
BACKGROUND In Brazil, few studies have investigated the prevalence of infection with the precore (PC) and basal core promoter (BCP) mutants of the hepatitis B virus (HBV). OBJECTIVES This study aimed to analyse the frequency of PC and BCP mutations among patients infected with HBV and to evaluate the association between the variants and advanced hepatic disease. METHODS A total of 161 patients infected with HBV were studied. To identify PC and BCP mutations, a 501-bp fragment of HBV DNA was amplified and sequenced. FINDINGS PC and BCP regions from HBV strains were successfully amplified and sequenced in 129 and 118 cases, respectively. PC and BCP mutations were detected in 61.0% and 80.6% of the cases, respectively. The A1762T/G1764A variant was identified in 36.7% of the patients with grade 1 and 2 liver fibrosis (29/79) and in 81.8% of the patients with grade 3 and 4 liver fibrosis (9/11) (p < 0.01); in 76.9% of the patients with cirrhosis (10/13) and in 38.1% of the patients without cirrhosis (40/105) (p = 0.01); and in 77.8% of the patients with hepatocellular carcinoma (HCC) (7/9) and in 39.4% of the patients without HCC (43/109) (p = 0.03). MAIN CONCLUSIONS A high prevalence of HBV PC and BCP mutants was found. The A1762T/G1764A variant was independently associated with advanced forms of liver fibrosis, hepatic cirrhosis, and HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Proteínas del Núcleo Viral / Virus de la Hepatitis B / Hepatitis B Crónica / Cirrosis Hepática Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2017 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Proteínas del Núcleo Viral / Virus de la Hepatitis B / Hepatitis B Crónica / Cirrosis Hepática Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2017 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil