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Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates
Brandolt, Tchana Martinez; Klafke, Gabriel Baracy; Gonçalves, Carla Vitola; Bitencourt, Laura Riffel; Martinez, Ana Maria Barral de; Mendes, Josiara Furtado; Meireles, Mário Carlos Araújo; Xavier, Melissa Orzechowski.
Afiliación
  • Brandolt, Tchana Martinez; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
  • Klafke, Gabriel Baracy; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
  • Gonçalves, Carla Vitola; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
  • Bitencourt, Laura Riffel; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
  • Martinez, Ana Maria Barral de; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
  • Mendes, Josiara Furtado; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
  • Meireles, Mário Carlos Araújo; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
  • Xavier, Melissa Orzechowski; Universidade Federal do Rio Grande. Laboratório de Micologia. Rio Grande. BR
Braz. j. microbiol ; Braz. j. microbiol;48(1): 145-150, Jan.-Mar. 2017. tab
Article en En | LILACS | ID: biblio-839344
Biblioteca responsable: BR1.1
ABSTRACT
Abstract Vulvovaginal candidiasis (VVC) is an infection of the genital mucosa caused by different species of the genus Candida. Considering the lack of data on this topic in the south of Brazil, this study aimed to assess the prevalence of Candida spp. in the cervical-vaginal mucosa of patients treated at a university hospital in southern Rio Grande do Sul, as well as the etiology and the susceptibility of the isolates against fluconazole, itraconazole, miconazole and nystatin. Samples were collected at the gynecology clinic of the Federal Hospital of the University of Rio Grande, and the isolates were identified using phenotypic and biochemical tests. The susceptibility analysis was performed according to the CLSI M27-A2 protocol. Of the 263 patients included, Candida spp. was isolated in 27%, corresponding to a prevalence of approximately 15% for both VVC and colonization. More than 60% of the isolates were identified as Candida albicans; C. non-albicans was isolated at a rate of 8.6% in symptomatic patients and 14.3% in asymptomatic patients. The prevalence of resistance against fluconazole and itraconazole was 42% and 48%, respectively; the minimal inhibitory concentration of miconazole ranged from 0.031 to 8 µg/mL, and that of nystatin ranged from 2 to >16 µg/mL. The high rate of resistance to triazoles observed in our study suggests the necessity of the association of laboratory exams to clinical diagnosis to minimize the practice of empirical treatments that can contribute to the development of resistance in the isolates.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Candida / Candidiasis Vulvovaginal Tipo de estudio: Guideline / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Pregnancy País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz. j. microbiol Asunto de la revista: MICROBIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Candida / Candidiasis Vulvovaginal Tipo de estudio: Guideline / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Pregnancy País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz. j. microbiol Asunto de la revista: MICROBIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil