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Association between hepatic steatosis and fibrosis and arthritis among US adults: A population-based study
Lu, Zhiming; Wu, Shaojie; Feng, Eryou; Chen, Xiaoli; Chen, Jinhua; Lin, Feitai.
Afiliación
  • Lu, Zhiming; Fujian Medical University. Union Hospital. Fuzhou. CN
  • Wu, Shaojie; Fuzhou City Second Hospital. Fuzhou. CN
  • Feng, Eryou; Fujian Medical University. Union Hospital. Fuzhou. CN
  • Chen, Xiaoli; Fuzhou City Second Hospital. Fuzhou. CN
  • Chen, Jinhua; Fujian Medical University. Union Hospital. Fuzhou. CN
  • Lin, Feitai; Fuzhou City Second Hospital. Fuzhou. CN
Clinics ; Clinics;79: 100378, 2024. tab, graf
Article en En | LILACS-Express | LILACS | ID: biblio-1569122
Biblioteca responsable: BR1.1
ABSTRACT
Abstract

Background:

Lipid metabolism factors may play a role in the development of arthritis and hepatic steatosis and fibrosis. The aim of this study was to explore the potential association between arthritis and hepatic steatosis and liver fibrosis. Materials and

methods:

The nationally representative sample from the National Health and Nutrition Examination Survey was analyzed, with data on arthritis diagnosis, subtype, and liver status obtained. Liver status was assessed using transient elastography. Hepatic steatosis was defined as a Controlled Attenuation Parameter (CAP) score ≥263 dB/m, and liver fibrosis status was defined as F0‒F4. Logistic regression models and subgroup analyses stratified by sex were used to evaluate the associations. Smooth curve fitting was used to describe the associations.

Results:

The present study of 6,840 adults aged 20 years or older found a significant positive correlation between arthritis and CAP in multivariate logistic regression analysis (β = 0.003, 95 % CI 0.001 to 0.0041, p < 0.001). Participants with arthritis had a higher risk of hepatic steatosis (OR = 1.248, 95 % CI 1.036 to 1.504, p = 0.020), particularly those with osteoarthritis or degenerative arthritis, but not rheumatoid arthritis (p = 0.847). The positive correlation was maintained in females (β = 0.004, 95 % CI 0.002 to 0.006, p < 0.001), but not in males. There was no significant relationship between arthritis and liver fibrosis (p = 0.508).

Conclusion:

This study indicates that there is a positive correlation between arthritis and hepatic steatosis, particularly in females. Nonetheless, there is no significant relationship between arthritis and the risk of liver fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil