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Diagnostic accuracy of interleukin-6, interleukin-10 and tumor necrosis factor alpha cytokine levels in patients with mild cognitive impairment: systematic review and meta-analysis / Precisão diagnóstica dos níveis das citocinas IL-6, IL-10 e TNF-α em pacientes com comprometimento cognitivo leve: revisão sistemática e metanálise
Aquino, Alana Mara Inácio de; Gomes, Kedma Anne Lima; Brito, Letícia Lorena Melo de; Lima, Luciana Domingos de; Gomes, Eneas Ricardo de Morais; Andrade, Suellen Mary Marinho dos Santos.
Afiliación
  • Aquino, Alana Mara Inácio de; Universidade Federal da Paraíba. Laboratório de Envelhecimento e Neurociências. João Pessoa. BR
  • Gomes, Kedma Anne Lima; Universidade Federal da Paraíba. Laboratório de Envelhecimento e Neurociências. João Pessoa. BR
  • Brito, Letícia Lorena Melo de; Universidade Federal da Paraíba. Laboratório de Envelhecimento e Neurociências. João Pessoa. BR
  • Lima, Luciana Domingos de; Universidade Federal da Paraíba. Laboratório de Envelhecimento e Neurociências. João Pessoa. BR
  • Gomes, Eneas Ricardo de Morais; Universidade Federal da Paraíba. Cento de Biotecnologia. Departamento de Biotecnolgia. João Pessoa. BR
  • Andrade, Suellen Mary Marinho dos Santos; Universidade Federal da Paraíba. Laboratório de Envelhecimento e Neurociências. João Pessoa. BR
Dement. neuropsychol ; 18: e20230027, 2024. tab, graf
Article en En | LILACS-Express | LILACS | ID: biblio-1564441
Biblioteca responsable: BR1.1
Ubicación: 1980-5764-DN-18-e20230027.xml
RESUMO
ABSTRACT There is growing evidence suggesting an association between neurodegeneration and inflammation playing a role in the pathogenesis of age-associated diseases, including Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI).

Objective:

A systematic review and meta-analysis were performed to verify evidence on the diagnostic accuracy parameters of the inflammatory cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α).

Methods:

A search of Medical Literature Analysis and Retrieval System Online (Medline), Scientific Electronic Library Online (SciELO), Web of Science and Science Direct databases was performed and nine observational studies associated with peripheral inflammatory biomarkers in MCI were identified. Mean (±standard deviation — SD) concentrations of these biomarkers and values of true positives, true negatives, false positives and false negatives for MCI and healthy controls (HC) were extracted from these studies.

Results:

Significantly higher levels of IL-10 were observed in subjects in the MCI group and Mini-Mental State Examination (MMSE) scores were lower compared to HC. For the other investigations, no differences were found between the groups. Our meta-analysis for the TNF-α biomarker revealed high heterogeneity between studies in terms of sensitivity and specificity.

Conclusion:

These findings do not support the involvement of inflammatory biomarkers for detection of MCI, although significant heterogeneity was observed. More studies are needed to evaluate the role of these cytokines in MCI, as well as in other stages of cognitive decline and all-cause dementias.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Dement. neuropsychol Asunto de la revista: NEUROCIENCIAS / NEUROLOGIA / PSICOLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Dement. neuropsychol Asunto de la revista: NEUROCIENCIAS / NEUROLOGIA / PSICOLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil