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Bacterial nanocellulose/calcium alginate hydrogel for the treatment of burns
Munhoz, Lauriene Luiza de Souza; Guillens, Luiz Carlos; Alves, Beatriz Candido; Nascimento, Maria Gabriela Oliveira Ferreira do; Meneguin, Andréia Bagliotti; Carbinatto, Fernanda Mansano; Arruda, Gabriela; Barud, Hernane da Silva; Aro, Andrea de; Casagrande, Laura de Roch; Silveira, Paulo Cesar Lock; Andrade, Thiago Antônio Moretti; Santos, Glaucia Maria Tech dos; Caetano, Guilherme Ferreira.
Afiliación
  • Munhoz, Lauriene Luiza de Souza; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
  • Guillens, Luiz Carlos; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
  • Alves, Beatriz Candido; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
  • Nascimento, Maria Gabriela Oliveira Ferreira do; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
  • Meneguin, Andréia Bagliotti; Universidade Estadual de São Paulo. School of Pharmaceutical Sciences. Araraquara. BR
  • Carbinatto, Fernanda Mansano; Universidade de Araraquara. BioPolymer and Biomaterial Laboratory. Araraquara. BR
  • Arruda, Gabriela; Universidade de Araraquara. BioPolymer and Biomaterial Laboratory. Araraquara. BR
  • Barud, Hernane da Silva; Universidade de Araraquara. BioPolymer and Biomaterial Laboratory. Araraquara. BR
  • Aro, Andrea de; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
  • Casagrande, Laura de Roch; Universidade do Extremo Sul Catarinense. Graduate Program in Science of Health. Criciúma. BR
  • Silveira, Paulo Cesar Lock; Universidade do Extremo Sul Catarinense. Graduate Program in Science of Health. Criciúma. BR
  • Andrade, Thiago Antônio Moretti; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
  • Santos, Glaucia Maria Tech dos; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
  • Caetano, Guilherme Ferreira; Centro Universitário Herminio Ometto de Araras. Graduate Program in Biomedical Sciences. Araras. BR
Acta cir. bras ; Acta cir. bras;39: e393324, 2024. tab, graf, ilus
Article en En | LILACS, VETINDEX | ID: biblio-1563651
Biblioteca responsable: BR68.1
Ubicación: BR68.1
ABSTRACT

Purpose:

Bacterial cellulose (BC) has shown high capacity for the treatment of wounds and burns, providing a moisty environment. Calcium alginate can be associated with BC to create gels that aid in wound debridement and contribute to appropriate wound healing. This study is aimed at characterizing and evaluating the use of bacterial cellulose/alginate gel in skin burns in rats.

Methods:

Cellulose and cellulose/alginate gels were compared regarding the capacity of liquid absorption, moisture, viscosity, and potential cytotoxicity. The 2nd degree burns were produced using an aluminum metal plate (2.0cm) at 120ºC for 20s on the back of rats. The animals were divided into non-treated, CMC(Carboxymethylcellulose), Cellulose(CMC with bacterial cellulose), and Cellulose/alginate(CMC with bacterial cellulose and alginate). The animals received topical treatment 3 times/week. Biochemical (MPO, NAG and oxidative stress), histomorphometry and immunohistochemical assays (IL-1ß IL-10 and VEGF) were conducted on the 14th, 21st, 28th, and 35th days.

Results:

Cellulose/Alginate gel showed higher absorption capacity and viscosity compared to Cellulose gel, with no cytotoxic effects. Cellulose/alginate presented lower MPO values, a higher percentage of IL-10, with greater and balanced oxidative stress profile.

Conclusions:

The use of cellulose/alginate gel reduced neutrophils and macrophage activation and showed greater anti-inflammatory response, which can contribute to healing chronic wounds and burns.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Quemaduras / Hidrogeles / Alginatos / Antiinflamatorios Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Quemaduras / Hidrogeles / Alginatos / Antiinflamatorios Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil