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Aerobic Metabolism Alterations as an Evidence of Underlying Deltamethrin Resistance Mechanisms in Triatoma infestans (Hemiptera: Reduviidae) / Alterações do metabolismo aeróbico como evidência de mecanismos subjacentes de resistência à deltametrina em Triatoma infestans (Hemiptera: Reduviidae)
Rolandi, Carmen; Acevedo, Gonzalo Roca; Schilman, Pablo E; Germano, Mónica D.
Afiliación
  • Rolandi, Carmen; Laboratório de Ecofisiologia de Insetos. Buenos Aires. AR
  • Acevedo, Gonzalo Roca; Centro de Investigaciones de Plagas e Insecticidas. Buenos Aires. AR
  • Schilman, Pablo E; Laboratório de Ecofisiologia de Insetos. Buenos Aires. AR
  • Germano, Mónica D; Instituto de Investigaciones Forestales y Agropecuarias Bariloche. Chubut. AR
Journal of Medical Entomology ; 57(6)2020. flux., graf.
Article en En | LILACS, BVSDIP | ID: biblio-1560941
Biblioteca responsable: BR1719.1
ABSTRACT
Abstract Triatoma infestans (Klug, 1834), the main vector of Chagas disease in Latin America, is regularly controlled by spraying the pyrethroid deltamethrin, to which some populations have developed resistance. The three main mechanisms of resistance are 1) metabolic resistance by overexpression or increased activity of detoxifying enzymes, 2) target site mutations, and 3) cuticle thickening/modification. We use open-flow respirometry to measure real-time H2O loss rate (V˙H2O) and CO2 production rate (V˙CO2), on nymphs from susceptible and resistant populations before and after exposure to the insecticide to understand the underlying mechanisms of resistance in live insects. Lack of differences in V˙H2O between populations suggested that cuticular thickness/composition is not acting as a relevant resistance mechanism. Similarly, there was no difference in resting V˙CO2, suggesting a trade-off between resistance mechanisms and other physiological processes. The increment in V˙CO2 after application of deltamethrin was similar in both populations, which suggested that while enhanced enzymatic detoxification may play a role in resistance expression in this population, the main mechanism involved should be a passive one such as target site mutations. Open-flow respirometry provided useful evidence for evaluating the mechanisms involved in deltamethrin resistance. Using this technique could improve efficiency of scientific research in the area of insecticide resistance management, leading to a faster decision making and hence improved control results.
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Texto completo: 1 Colección: 01-internacional Base de datos: BVSDIP / LILACS Asunto principal: Resistencia a los Insecticidas / Insecticidas Idioma: En Revista: Journal of Medical Entomology Año: 2020 Tipo del documento: Article País de afiliación: Argentina
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: BVSDIP / LILACS Asunto principal: Resistencia a los Insecticidas / Insecticidas Idioma: En Revista: Journal of Medical Entomology Año: 2020 Tipo del documento: Article País de afiliación: Argentina