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Adrenal morphology and cortical function in patients with extrapulmonary tuberculosis: response to antituberculosis treatment
Laway, Bashir Ahmad; Blouria, Bhanu Pratap Singh; Jan, Rafi Ahmad; Bhat, Moomin Hussain; Choh, Naseer Ahmad.
Afiliación
  • Laway, Bashir Ahmad; Sher-I-Kashmir Institute of Medical Sciences. Department of Endocrinology. Srinagar. IN
  • Blouria, Bhanu Pratap Singh; Sher-I-Kashmir Institute of Medical Sciences. General Medicine. Srinagar. IN
  • Jan, Rafi Ahmad; Sher-I-Kashmir Institute of Medical Sciences. General Medicine. Srinagar. IN
  • Bhat, Moomin Hussain; Sher-I-Kashmir Institute of Medical Sciences. Department of Endocrinology. Srinagar. IN
  • Choh, Naseer Ahmad; Sher-I-Kashmir Institute of Medical Sciences. Radio Diagnosis and Imaging. Srinagar. IN
Arch. endocrinol. metab. (Online) ; 68: e210514, 2024. tab
Article en En | LILACS-Express | LILACS | ID: biblio-1556957
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT

Objective:

Enlargement of the adrenal glands and variable adrenocortical function have been reported in patients with pulmonary tuberculosis and, in a few studies, in patients with extrapulmonary tuberculosis (EPTB). However, none of the studies have evaluated the course of the adrenal morphology in these patients. Subjects and

methods:

Prospective study including 37 patients with EPTB and 37 healthy age- and sex-matched controls. The adrenal function was evaluated by measurement of cortisol levels at baseline and after stimulation with ACTH (Acton Prolongatum) before and 6 months after antituberculosis treatment. The size of both adrenal glands was evaluated using 64-slice computed tomography (CT) scanning before and 6 months after treatment. The findings were compared with those in a group of healthy matched controls.

Results:

Clinical and biochemical parameters were comparable between groups. The mean baseline serum cortisol level was significantly lower in the EPTB group (397.1 ± 184.9 nmol/L) compared with the control group (696.3 ± 101.8 nmol/L). Compared with controls, patients with EPTB had significantly lower mean cortisol levels at baseline and 1 hour after ACTH, both before (397 ± 184.9 nmol/L and 750.7 ± 176.8 nmol/L, respectively) and after (529.7 ± 100.4 nmol/L and 1017.2 ± 119.7 nmol/L, respectively) antituberculosis treatment. Both the length and thickness of the right and left adrenal glands were greater in patients with EPTB than in controls but became comparable to those in controls after treatment completion.

Conclusions:

Patients with EPTB have an enlarged adrenal size and low baseline and stimulated serum cortisol levels. After treatment completion, cortisol levels increased significantly, and the adrenal size normalized in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Brasil