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Metabolic and ultrastructural renal changes in adult Wistar rats fed by a cafeteria diet
Santos, Priscila Fernandes dos; Souza, Diogo Benchimol de; Torres, Eduardo José Lopes; Costa, Waldemar Silva; Sampaio, Francisco José Barcellos; Gregorio, Bianca Martins.
Afiliación
  • Santos, Priscila Fernandes dos; Universidade do Estado do Rio de Janeiro. Biomedical Center. Department of Anatomy. Rio de Janeiro. BR
  • Souza, Diogo Benchimol de; Universidade do Estado do Rio de Janeiro. Biomedical Center. Department of Anatomy. Rio de Janeiro. BR
  • Torres, Eduardo José Lopes; Universidade do Estado do Rio de Janeiro. Biomedical Center. Department of Microbiology, Immunology and Parasitology. Rio de Janeiro. BR
  • Costa, Waldemar Silva; Universidade do Estado do Rio de Janeiro. Biomedical Center. Department of Anatomy. Rio de Janeiro. BR
  • Sampaio, Francisco José Barcellos; Universidade do Estado do Rio de Janeiro. Biomedical Center. Department of Anatomy. Rio de Janeiro. BR
  • Gregorio, Bianca Martins; Universidade do Estado do Rio de Janeiro. Biomedical Center. Department of Anatomy. Rio de Janeiro. BR
Acta cir. bras ; 39: e392224, 2024. tab, ilus
Article en En | LILACS, VETINDEX | ID: biblio-1556673
Biblioteca responsable: BR68.1
Ubicación: BR68.1
ABSTRACT

Purpose:

To evaluate, by quantitative and qualitative methods, the glomerular ultrastructure in Wistar rats fed a cafeteria diet.

Methods:

Male Wistar rats were divided into two groups at 21 days of age control (C, n = 10) and cafeteria diet (CAF, n = 8). The animals were followed up until 5 months of age, followed by euthanasia. The blood, kidneys, and fat deposits­­epididymal, retroperitoneal, and subcutaneous­­were extracted and analyzed. Data were analyzed by Student's t test, and p < 0.05 was considered statistically significant.

Results:

The cafeteria diet promoted glucose intolerance, hyperglycemia (p < 0.0001), and deposition of retroperitoneal fat (p < 0.005). Scanning electron microscopy revealed that the length of the foot process was similar in both groups. The quantitative analyses by transmission electron microscopy revealed that the cafeteria diet reduced the thickness of the glomerular basement membrane (p < 0.05).

Conclusions:

The intake of lipids and simple carbohydrates were found to be associated with alteration in the glomerular ultrastructure. However, more studies are needed to evaluate not only the effects of high-protein and high-fat diets on components of the glomerular filtration barrier, but also renal physiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Microscopía Electrónica de Rastreo / Ratas Wistar / Dieta / Riñón Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Microscopía Electrónica de Rastreo / Ratas Wistar / Dieta / Riñón Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil