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HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women / HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women
Alonso, Selena; Vidal, Marta; Olalla, Gemma Ruiz; Gonzalez, Raquel; Jairoce, Chenjerai; Manaca, M Nelia; Santiago, Miquel Vázquez; Balcells, Reyes; Vala, Anifa; Ruperez, María; Cistero, Pau; Soro, Laura Fuente; Angov, Evelina 5; Coppel, Ross L 6; Geimain, Benoit; Cavanagh, David; Beeson, James G; Nhacolo, Arsenio; Sevene, Esperança; Aponte, John J; Macete, Eusébio; Aguilar, Ruth; Mayor, Alfredo; Menendez, Clara; Dobano, Carlota; Moncunill, Gemma.
Afiliación
  • Alonso, Selena; ISGlobal, Hospital Clínic - Universitat de Barcelona. Barcelona. ES
  • Vidal, Marta; ISGlobal, Hospital Clínic - Universitat de Barcelona. Barcelona. ES
  • Olalla, Gemma Ruiz; ISGlobal, Hospital Clínic - Universitat de Barcelona. Barcelona. ES
  • Gonzalez, Raquel; ISGlobal, Hospital Clínic - Universitat de Barcelona. Barcelona. ES
  • Jairoce, Chenjerai; Centro de Investigação em Saúde de Manhiça (CISM). Maputo. MZ
  • Manaca, M Nelia; Centro de Investigação em Saúde de Manhiça (CISM). Maputo. MZ
  • Santiago, Miquel Vázquez; ISGlobal, Hospital Clínic - Universitat de Barcelona. Barcelona. ES
  • Balcells, Reyes; LSGlobal, Hospital Clínic - Universitat de Barcelona. Centro de Investigação em Saúde de Manhiça. Barcelona. ES
  • Vala, Anifa; Centro de Investigação em Saúde de Manhiça (CISM). Maputo. MZ
  • Ruperez, María; ISGlobal, Hospital Clínic - Universitat de Barcelona. Maputo. MZ
  • Cistero, Pau; ISGlobal, Hospital Clínic - Universitat de Barcelona. Maputo. ES
  • Soro, Laura Fuente; ISGlobal, Hospital Clínic - Universitat de Barcelona. Centro de Investigação em Saúde de Manhiça (CISM). Barcelona. ES
  • Angov, Evelina 5; U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA. marlandy. US
  • Coppel, Ross L 6; nfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC, Australia. Melbourne. AU
  • Geimain, Benoit; Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge UMR_S1134, Laboratoire d'Excellence GR-Ex, Paris, France. Paris. FR
  • Cavanagh, David; nstitute of Immunology & Infection Research and Centre for Immunity, Infection & Evolution, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, King's Buildings, Charlotte Auerbach Rd, Edinburgh, EH9 3FL, UK. GB
  • Beeson, James G; Burnet Institute, Melbourne, VIC, 3004, Australia. AU
  • Nhacolo, Arsenio; Centro de Investigação em Saúde de Manhiça (CISM), Rua 12, Cambeve, Vila de Manhiça, CP 1929, Maputo, Mozambique. Maputo. MZ
  • Sevene, Esperança; Centro de Investigação em Saúde de Manhiça (CISM). Maputo. MZ
  • Aponte, John J; ISGlobal, Hospital Clínic - Universitat de Barcelona. Centro de Investigação em Saúde de Manhiça (CISM). Barcelona. ES
  • Macete, Eusébio; Centro de Investigação em Saúde de Manhiça (CISM). Maputo. MZ
  • Aguilar, Ruth; ISGlobal, Hospital Clínic - Universitat de Barcelona. Barcelona. ES
  • Mayor, Alfredo; ISGlobal, Hospital Clínic - Universitat de Barcelona. Centro de Investigação em Saúde de Manhiça (CISM). Barcelona. ES
  • Menendez, Clara; ISGlobal, Hospital Clínic - Universitat de Barcelona. Centro de Investigação em Saúde de Manhiça (CISM). Barcelona. ES
  • Dobano, Carlota; ISGlobal, Hospital Clínic - Universitat de Barcelona. Centro de Investigação em Saúde de Manhiça (CISM). Barcelona. ES
  • Moncunill, Gemma; ISGlobal, Hospital Clínic - Universitat de Barcelona. Centro de Investigação em Saúde de Manhiça (CISM). Barcelona. ES
J. infect ; J. infect;82(4): 45-57, abr. 2021.
Article en En | AIM, RSDM | ID: biblio-1526514
Biblioteca responsable: MZ1.1
ABSTRACT
Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses.

Methods:

In a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer.

Results:

Maternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2.

Conclusions:

We found lower maternally transferred antibodies in HIV-exposed infants and those born from mothers with placental malaria, which may underlie increased susceptibility to malaria in these children.
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Texto completo: 1 Colección: 06-national / MZ Base de datos: AIM / RSDM Asunto principal: VIH / Sangre Fetal Límite: Humans Idioma: En Revista: J. infect Año: 2021 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 06-national / MZ Base de datos: AIM / RSDM Asunto principal: VIH / Sangre Fetal Límite: Humans Idioma: En Revista: J. infect Año: 2021 Tipo del documento: Article