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Antibacterial and antifungal activity of curcumin and methylene blue associated with laser on bacterial and fungal strains
Cardoso, Brenda Ellen Meneses; Medeiros, Ana Andreza Albuquerque; Martins, Matheus Lopes; Sousa, André Luca Araújo de; Alves, Nathanael dos Santos; Veras, Leiz Maria Costa; Araújo, Alyne Rodrigues; Pinto, Antonione Santos Bezerra.
Afiliación
  • Cardoso, Brenda Ellen Meneses; Institute of Higher Education of Vale do Parnaíba. Parnaiba. BR
  • Medeiros, Ana Andreza Albuquerque; Institute of Higher Education of Vale do Parnaíba. Parnaiba. BR
  • Martins, Matheus Lopes; Institute of Higher Education of Vale do Parnaíba. Parnaiba. BR
  • Sousa, André Luca Araújo de; State University of Piauí. Parnaiba. BR
  • Alves, Nathanael dos Santos; Parnaiba Delta Federal University. Parnaiba. BR
  • Veras, Leiz Maria Costa; Parnaiba Delta Federal University. Parnaiba. BR
  • Araújo, Alyne Rodrigues; Parnaiba Delta Federal University. Parnaiba. BR
  • Pinto, Antonione Santos Bezerra; Institute of Higher Education of Vale do Parnaíba. Parnaiba. BR
Rev. Ciênc. Saúde ; 13(4): 33-37, Dezembro 2023.
Article en En | LILACS | ID: biblio-1526387
Biblioteca responsable: BR375.1
ABSTRACT

Objective:

To analyze the effect of methylene blue and 10% curcumin in fungi and bacteria through an in vitrostudy using photodynamic therapy (PDT).

Methods:

Curcumin and methylene blue were photosensitized by a Photon Lase III laser applied for 90 s in a dark environment within a laminar flow chamber. Enterococcus faecalisand Candida albicans strains were cultured and standardized.Then, a minimum inhibitoryconcentration (MIC) assay was conducted for these photosensitizers, with concentration variations and incubation to evaluate their antimicrobial activity.

Results:

With PDT, Curcumin had significant antibacterial activity against E. faecalis (MIC = 250 µg/mL).In contrast, methylene blue had antibacterial activity against E. faecalis (MIC < 12.5 µg/mL with PDT) and antifungal activity against C. albicans (MIC <12.5 µg/mL with or without PDT).Both agents showed greater efficacy in the presence of the laser.The results suggest that curcumin and methylene blue associated with laser may effectively treat microbial infections.

Conclusion:

Further research is needed to evaluate the efficacy and safety of using these agents in animal and human models and theireffectiveness against different bacterial and fungal strains.
Licencia
CC BY-NC-SA - Atribuição-NãoComercial-CompartilhaIgual

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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Risk_factors_studies Idioma: En Revista: Rev. Ciênc. Saúde Asunto de la revista: Ciˆncias da Sa£de / Medicina Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Tipo de estudio: Risk_factors_studies Idioma: En Revista: Rev. Ciênc. Saúde Asunto de la revista: Ciˆncias da Sa£de / Medicina Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil