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Implementation of an organized colorectal cancer screening program through quantitative fecal immunochemical test followed by colonoscopy in an urban low-income community: Guidance and strategies
Ribeiro Jr., Ulysses; Safatle-Ribeiro, Adriana Vaz; Sorbello, Maurício; Kishi, Poliana Helena Rosolem; Cohend, Diane Dede; Mattar, Rejane; Castilho, Vera Lucia Pagliusi; Goncalves, Elenice Messias Do Nascimento; Kawaguti, Fábio; Marques, Carlos Frederico Sparapan; Alves, Venâncio Avancini Ferreira; Nahas, Sérgio Carlos; Eluf-Neto, José.
Afiliación
  • Ribeiro Jr., Ulysses; Universidade de São Paulo. Departments of Gastroenterology. São Paulo. BR
  • Safatle-Ribeiro, Adriana Vaz; Universidade de São Paulo. Departments of Gastroenterology. São Paulo. BR
  • Sorbello, Maurício; Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas. São Paulo. BR
  • Kishi, Poliana Helena Rosolem; Universidade de São Paulo. Preventive Medicine. São Paulo. BR
  • Cohend, Diane Dede; Universidade de São Paulo. Preventive Medicine. São Paulo. BR
  • Mattar, Rejane; Universidade de São Paulo. Departments of Gastroenterology. São Paulo. BR
  • Castilho, Vera Lucia Pagliusi; Universidade de São Paulo. Pathology. São Paulo. BR
  • Goncalves, Elenice Messias Do Nascimento; Universidade de São Paulo. Pathology. São Paulo. BR
  • Kawaguti, Fábio; Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas. São Paulo. BR
  • Marques, Carlos Frederico Sparapan; Universidade de São Paulo. Departments of Gastroenterology. São Paulo. BR
  • Alves, Venâncio Avancini Ferreira; Universidade de São Paulo. Pathology. São Paulo. BR
  • Nahas, Sérgio Carlos; Universidade de São Paulo. Departments of Gastroenterology. São Paulo. BR
  • Eluf-Neto, José; Fundação Oncocentro de São Paulo. São Paulo. BR
Clinics ; Clinics;78: 100278, 2023. tab, graf
Article en En | LILACS-Express | LILACS | ID: biblio-1520689
Biblioteca responsable: BR1.1
ABSTRACT
Abstract Fecal Immunochemical Test (FIT) followed by a colonoscopy is an efficacious strategy to improve the adenoma detection rate and Colorectal Cancer (CRC). There is no organized national screening program for CRC in Brazil. The aim of this research was to describe the implementation of an organized screening program for CRC through FIT followed by colonoscopy, in an urban low-income community of São Paulo city. The endpoints of the study were FIT participation rate, FIT positivity rate, colonoscopy compliance rate, Positive Predictive Values (PPV) for adenoma and CRC, and the rate of complications. From May 2016 to October 2019, asymptomatic individuals, 50-75 years old, received a free kit to perform the FIT. Positive FIT (≥ 50 ng/mL) individuals were referred to colonoscopy. 10,057 individuals returned the stool sample for analysis, of which (98.2%) 9,881 were valid. Women represented 64.8% of the participants. 55.3% of individuals did not complete elementary school. Positive FIT was 7.8% (776/9881). The colonoscopy compliance rate was 68.9% (535/776). There were no major colonoscopy complications. Adenoma were detected in 63.2% (332/525) of individuals. Advanced adenomatous lesions were found in 31.4% (165/525). CRC was diagnosed in 5.9% (31/525), characterized as adenocarcinoma in situ in 3.2% (1/31), intramucosal in 29% (9/31), and invasive in 67.7% (21/31). Endoscopic treatment with curative intent for CRC was performed in 45.2% (14/31) of the cases. Therefore, in an urban low-income community, an organized CRC screening using FIT followed by colonoscopy ensued a high participation rate, and high predictive positive value for both, adenoma and CRC.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil