The effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative peritoneal adhesion formation in rats
Acta cir. bras
; 32(1): 2722-27, Jan. 2017. ilus
Article
en En
| LILACS, VETINDEX
| ID: biblio-1456230
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
ABSTRACT
Purpose:
To assess the effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative adhesion in animal models.Methods:
Sixty males Albino Wistar rats aged 5 to 6 weeks were classified into five groups receiving none, heparin, PRP, silver nanoparticles, PRP plus silver nanoparticles intraperitoneally. After 2 weeks, the animals underwent laparotomy and the damaged site was assessed for peritoneal adhesions severity.Results:
The mean severity scores were 2.5 ± 0.9, 2.16 ± 0.7, 1.5 ± 0.5, 2.66 ± 0.88, and 2.25 ± 0.62 in the control, heparin, PRP, silver and PRP plus silver groups, respectively with significant intergroup difference (p = 0.004). The highest effective material for preventing adhesion formation was PRP followed by heparin and PRP plus silver. Moreover, compared to the controls, only use of PRP was significantly effective, in terms of adhesion severity (p = 0.01) .Conclusion:
Platelet-rich plasma alone may have the highest efficacy for preventing postoperative peritoneal adhesions in comparison with heparin, silver nanoparticles and PRP plus silver nanoparticles.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
/
VETINDEX
Asunto principal:
Peritoneo
/
Heparina
/
Plasma Rico en Plaquetas
/
Nanopartículas del Metal
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2017
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Brasil