Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology
Rev. méd. hondur
; 90(2): 160-166, jul.-dic. 2022. ilus
Article
en Es
| LILACS, BIMENA
| ID: biblio-1434054
Biblioteca responsable:
HN1.1
ABSTRACT
Worldwide, leptospirosis is the most highly prevalent zoonosis. Although the wide range of clinical manifestations of leptospirosis in humans is well-documented, knowledge of the mechanisms through which this pathogen causes kidney disease remains limited. This narrative review of the scientific literature presents experimental studies of pathophysiology and kidney disease in leptospirosis, both in humans and animals, and the results show that virulence factors are involved in kidney damage by inducing interstitial tubular nephritis, which is the most frequent pathological manifestation, additionally, to the acute non-oliguric renal lesion with hypokalemia, and loss of magnesium and sodium. Finally, it is concluded that in leptospirosis, the initial lesion in the kidney is caused by damage to the cell membrane of the proximal tubular region cells by pathogenic Leptospira virulence factors, thus exacerbating the immune response
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
BIMENA
/
LILACS
Asunto principal:
Leptospira
/
Leptospirosis
Límite:
Humans
Idioma:
Es
Revista:
Rev. méd. hondur
Asunto de la revista:
MEDICINA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Colombia
Pais de publicación:
Honduras