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18ß-glycyrrhetinic acid attenuates global cerebral ischemia/reperfusion-induced cardiac damage in C57BL/J6 mice
Türkmen, Nese Basak; Yüce, Hande; Taslidere, Asli; Sahin, Yasemin; Ayhan, Idris; UNÜVAR, Songül; Çiftçi, Osman.
Afiliación
  • Türkmen, Nese Basak; Inonu University. Faculty of Pharmacy. Department of Pharmaceutical Toxicology. Malatya. TR
  • Yüce, Hande; Inonu University. Faculty of Pharmacy. Department of Pharmaceutical Toxicology. Malatya. TR
  • Taslidere, Asli; Inonu University. Faculty of Medicine. Department of Histology and Embryology. Malatya. TR
  • Sahin, Yasemin; Pamukkale University. Faculty of Medicine. Department of Medicinal Pharmacology. Denizli. TR
  • Ayhan, Idris; The Scientific and Technological Research Council of Turkey (TÜBITAK). Department of Health Sciences. Ankara. TR
  • UNÜVAR, Songül; Inonu University. Faculty of Pharmacy. Department of Pharmaceutical Toxicology. Malatya. TR
  • Çiftçi, Osman; Pamukkale University. Faculty of Medicine. Department of Medicinal Pharmacology. Denizli. TR
Braz. J. Pharm. Sci. (Online) ; 58: e21219, 2022. tab, graf
Article en En | LILACS | ID: biblio-1420483
Biblioteca responsable: BR40.1
Ubicación: BR40.1
ABSTRACT
Abstract The aim of the present study is to investigate the cardioprotective effects of 18ß-glycyrrhetinic acid (18ß -GA) against oxidative and histological damage caused by global cerebral ischemia/ reperfusion (I/R) in C57BL/J6 mice. All male mice (n40) were randomly divided into four groups (1) sham-operated (Sham), (2) I/R, (3) 18ß-GA, and (4) 18ß -GA+I/R. Ischemia was not applied to the sham and 18ß-GA groups. In the I/R group, the bilateral carotid arteries were clipped for 15 min to induce ischemia, and the mice were treated with the vehicle for 10 days. In the 18ß-GA group, the mice were given 18ß-GA (100 mg/kg) for 10 days following a median incision without carotid occlusion. In the 18ß-GA+I/R group, the ischemic procedure performed to the I/R model was applied to the animals and afterwards they were intraperitoneally (i.p.) treated with 18ß-GA (100 mg/kg) for 10 days. It was found that global cerebral I/R increased TBARS levels and decreased antioxidant parameters. The 18ß-GA treatment decreased the level of TBARS and increased GSH, GPx, CAT, SOD activities. Also, the control group cardiac tissue samples were observed to have a normal histological appearance with the Hematoxylin-Eosin staining method. Histopathological damage was observed in the heart tissue samples belonging to the I/R group. The 18ß-GA treatment ameliorates oxidative and histological injury in the heart tissue after global ischemia reperfusion, and may be a beneficial alternative treatment
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Cardiotónicos / Reperfusión / Isquemia Encefálica Límite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Cardiotónicos / Reperfusión / Isquemia Encefálica Límite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Brasil